Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C27H24FN9O2 |
Molecular Weight | 525.537 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1C=C(C=N1)[C@]2(N[C@H](CC3=C2NC4=C3C=CC=C4)C5=NC(=CN5)C6=NC=C(F)C=C6)C7=NN(C)C(=O)O7
InChI
InChIKey=RETOYYSEVCBIRN-JIPXPUAJSA-N
InChI=1S/C27H24FN9O2/c1-3-37-14-15(11-31-37)27(25-35-36(2)26(38)39-25)23-18(17-6-4-5-7-19(17)32-23)10-21(34-27)24-30-13-22(33-24)20-9-8-16(28)12-29-20/h4-9,11-14,21,32,34H,3,10H2,1-2H3,(H,30,33)/t21-,27-/m1/s1
Molecular Formula | C27H24FN9O2 |
Molecular Weight | 525.537 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:44:43 GMT 2023
by
admin
on
Sat Dec 16 08:44:43 GMT 2023
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Record UNII |
N9WN9W54QJ
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Record Status |
Validated (UNII)
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Record Version |
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-
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1235995-16-0
Created by
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122179477
Created by
admin on Sat Dec 16 08:44:43 GMT 2023 , Edited by admin on Sat Dec 16 08:44:43 GMT 2023
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N9WN9W54QJ
Created by
admin on Sat Dec 16 08:44:43 GMT 2023 , Edited by admin on Sat Dec 16 08:44:43 GMT 2023
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ACTIVE MOIETY |
MK-1421 sstr3 binding IC50 = 2.3 NM. , sstr3 func. antag IC50 = 1.1 NM.
ABSTRACT: The imidazolyl-tetrahydro-.BETA.-carboline class of sstr3 antagonists have demonstrated efficacy in a murine model of glucose excursion and may have potential as a treatment for type 2 diabetes. The first candidate in this class caused unacceptable QTc
interval prolongation in oral, telemetrized cardiovascular (CV) dogs. Herein, we describe our
efforts to identify an acceptable candidate without CV effects. These efforts resulted in the
identification of (1R,3R)-3-(4-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl)-1-(1-ethyl-pyrazol-4-
yl)-1-(3-methyl-1,3,4-oxadiazol-3H-2-one-5-yl)-2,3,4,9-tetrahydro-1H-.BETA.-carboline (17e, MK-1421).
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