Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H20ClN3O2 |
| Molecular Weight | 453.92 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=CC(Cl)=C1C(=O)NNC(=O)C2=CC(C#CC3=CC4=CC=CC=C4N=C3)=C(C)C=C2
InChI
InChIKey=ZQOBVMHBVWNVBG-UHFFFAOYSA-N
InChI=1S/C27H20ClN3O2/c1-17-10-12-22(26(32)30-31-27(33)25-18(2)6-5-8-23(25)28)15-20(17)13-11-19-14-21-7-3-4-9-24(21)29-16-19/h3-10,12,14-16H,1-2H3,(H,30,32)(H,31,33)
| Molecular Formula | C27H20ClN3O2 |
| Molecular Weight | 453.92 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1378 ng/mL |
48 mg single, oral dose: 48 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
3775 ng/mL |
192 mg single, oral dose: 192 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
6632 ng/mL |
384 mg single, oral dose: 384 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
1395 ng/mL |
48 mg 1 times / day multiple, oral dose: 48 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
5377 ng/mL |
192 mg 1 times / day multiple, oral dose: 192 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
6632 ng/mL |
384 mg 1 times / day multiple, oral dose: 384 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
164 ng/mL |
6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
255 ng/mL |
12 mg single, oral dose: 12 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
410 ng/mL |
18 mg single, oral dose: 18 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
385 ng/mL |
24 mg single, oral dose: 24 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
964 ng/mL |
48 mg single, oral dose: 48 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
1359 ng/mL |
96 mg single, oral dose: 96 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
1826 ng/mL |
192 mg single, oral dose: 192 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
3029 ng/mL |
384 mg single, oral dose: 384 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
182 ng/mL |
6 mg 1 times / day multiple, oral dose: 6 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
301 ng/mL |
12 mg 1 times / day multiple, oral dose: 12 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
309 ng/mL |
18 mg 1 times / day multiple, oral dose: 18 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
715 ng/mL |
24 mg 1 times / day multiple, oral dose: 24 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
1110 ng/mL |
48 mg 1 times / day multiple, oral dose: 48 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
2803 ng/mL |
96 mg 1 times / day multiple, oral dose: 96 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
3234 ng/mL |
192 mg 1 times / day multiple, oral dose: 192 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
4512 ng/mL |
384 mg 1 times / day multiple, oral dose: 384 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
5.5 ng/mL |
384 mg 1 times / day multiple, oral dose: 384 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB cerebrospinal fluid | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
5.2 ng/mL |
192 mg 1 times / day multiple, oral dose: 192 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB cerebrospinal fluid | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
0.8 ng/mL |
48 mg 1 times / day multiple, oral dose: 48 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB cerebrospinal fluid | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
8871 ng × h/mL |
48 mg single, oral dose: 48 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
34474 ng × h/mL |
192 mg single, oral dose: 192 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
47606 ng × h/mL |
384 mg single, oral dose: 384 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
12854 ng × h/mL |
48 mg 1 times / day multiple, oral dose: 48 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
44131 ng × h/mL |
192 mg 1 times / day multiple, oral dose: 192 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
54879 ng × h/mL |
384 mg 1 times / day multiple, oral dose: 384 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
794 ng × h/mL |
6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
2044 ng × h/mL |
12 mg single, oral dose: 12 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
2730 ng × h/mL |
18 mg single, oral dose: 18 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
2689 ng × h/mL |
24 mg single, oral dose: 24 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
5308 ng × h/mL |
48 mg single, oral dose: 48 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
10176 ng × h/mL |
96 mg single, oral dose: 96 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
18629 ng × h/mL |
192 mg single, oral dose: 192 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
29874 ng × h/mL |
384 mg single, oral dose: 384 mg route of administration: Oral experiment type: SINGLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
1250 ng × h/mL |
6 mg 1 times / day multiple, oral dose: 6 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
3250 ng × h/mL |
12 mg 1 times / day multiple, oral dose: 12 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
3371 ng × h/mL |
18 mg 1 times / day multiple, oral dose: 18 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
5724 ng × h/mL |
24 mg 1 times / day multiple, oral dose: 24 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
7912 ng × h/mL |
48 mg 1 times / day multiple, oral dose: 48 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
17129 ng × h/mL |
96 mg 1 times / day multiple, oral dose: 96 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
33788 ng × h/mL |
192 mg 1 times / day multiple, oral dose: 192 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
43821 ng × h/mL |
384 mg 1 times / day multiple, oral dose: 384 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
58.7 ng × h/mL |
384 mg 1 times / day multiple, oral dose: 384 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB cerebrospinal fluid | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
74.5 ng × h/mL |
192 mg 1 times / day multiple, oral dose: 192 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB cerebrospinal fluid | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
10 ng × h/mL |
48 mg 1 times / day multiple, oral dose: 48 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
VODOBATINIB cerebrospinal fluid | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:19:20 GMT 2025
by
admin
on
Mon Mar 31 23:19:20 GMT 2025
|
| Record UNII |
N8Q12KU2SW
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Code | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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FDA ORPHAN DRUG |
687119
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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N8Q12KU2SW
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
|
PRIMARY | |||
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GH-18
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
|
PRIMARY | |||
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1388803-90-4
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
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PRIMARY | |||
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11506
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
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PRIMARY | |||
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89884852
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
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PRIMARY | |||
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C174748
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
|
PRIMARY | |||
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300000027516
Created by
admin on Mon Mar 31 23:19:20 GMT 2025 , Edited by admin on Mon Mar 31 23:19:20 GMT 2025
|
PRIMARY |
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