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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H36O2
Molecular Weight 344.5307
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of BECOCALCIDIOL

SMILES

[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C3C[C@@H](O)C(=C)[C@H](O)C3)[C@@H](C)CC

InChI

InChIKey=QSLUXQQUPXBIHH-YHSKWIAJSA-N
InChI=1S/C23H36O2/c1-5-15(2)19-10-11-20-18(7-6-12-23(19,20)4)9-8-17-13-21(24)16(3)22(25)14-17/h8-9,15,19-22,24-25H,3,5-7,10-14H2,1-2,4H3/b18-9+/t15-,19+,20-,21+,22+,23+/m0/s1

HIDE SMILES / InChI

Molecular Formula C23H36O2
Molecular Weight 344.5307
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 1
Optical Activity UNSPECIFIED

Description

Becocalcidiol is a vitamin D analog participated in phase II clinical trials as a topical treatment for psoriasis. Therapy was safe and well tolerated, however further studies were discontinued.

Originator

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
One hundred and eighty-five subjects with chronic plaque-type psoriasis affecting 2-10% of their body surface area took part in a multicentre, double-blind, parallel-group, vehicle-controlled, randomized controlled trial comparing topical application of placebo, becocalcidiol 75 microg g(-1) once daily (low dose) or becocalcidiol twice daily (high dose) for 8 weeks.
Route of Administration: Topical
Substance Class Chemical
Record UNII
N75R59YD0F
Record Status Validated (UNII)
Record Version