FALIPAMIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H32N2O5
Molecular Weight	428.5213
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(CCN(C)CCCN2CC3=C(C=C(OC)C(OC)=C3)C2=O)C=C1OC

InChI

InChIKey=UUMGNNQOCVDZDG-UHFFFAOYSA-N

InChI=1S/C24H32N2O5/c1-25(12-9-17-7-8-20(28-2)21(13-17)29-3)10-6-11-26-16-18-14-22(30-4)23(31-5)15-19(18)24(26)27/h7-8,13-15H,6,9-12,16H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C24H32N2O5
Molecular Weight	428.5213
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800000360 | https://www.ncbi.nlm.nih.gov/pubmed/3691560 | https://www.ncbi.nlm.nih.gov/pubmed/7516006 | https://www.ncbi.nlm.nih.gov/pubmed/3330525

Falipamil (AQ-A 39), a bradycardiac agent is a calcium channel antagonist. Falipamil can be used to normalize sinus rate in patients with sinus tachycardia of various origin, particularly in intensive care, in acute ischemic heart disease, in anesthesia, and in surgery cases. Falipamil development has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Heart rate and cardiovascular disease: an alternative to Beta blockers.	2009	19936114
[Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].	2006-02	16502273
Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?	2003-06	12808482
[Therapy of perioperative sinus tachycardia with the new calcium antagonist falipamil].	1987-11	3440040
Beneficial effects of two specific bradycardic agents AQ-A39 (falipamil) and AQ-AH 208 on reversible myocardial reperfusion damage in anesthetized dogs.	1986-08	3735124
[The action of a new calcium antagonist 5,6-dimethoxy-2-(3 [(alpha-(3,4-dimethoxy)-phenylethyl)methylamino] propyl)-phthalimidine hydrochloride (AQ-A 39cl) on hemodynamics and ischemia parameters in exercise ECG of patients with coronary heart disease].	1985	4074444

Sample Use Guides

In Vivo Use Guide

1.5-2 mg/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:15 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:15 GMT 2025`
Record UNII	N6A93ZMN7U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

falipamil [INN]

Preferred Name

English

FALIPAMIL

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333