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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H16O
Molecular Weight 152.2334
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAMPHOR (NATURAL)

SMILES

CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2

InChI

InChIKey=DSSYKIVIOFKYAU-XCBNKYQSSA-N
InChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H16O
Molecular Weight 152.2334
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Camphor is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. Topically, camphor is used to relieve pain. It has been used to treat warts, cold sores, hemorrhoids, and osteoarthritis. It has also been applied topically as an analgesic and an antipruritic. It has been used as a counterirritant, and to increase local blood flow. Camphor has frequently been used topically to treat respiratory tract diseases involving mucous membrane inflammation. It is sometimes used topically to treat cardiac symptoms. Camphor is also used topically as an eardrop, and for treating minor burns. In inhalation therapy, camphor is used as an antitussive. Orally, camphor is used as an expectorant, antiflatulent, and for treating respiratory tract diseases. Today, most camphor is synthetic. It is approved by the FDA as a topical antitussive. Camphor is produced synthetically from the oil of turpentine. It has been used for centuries for its medicinal features, in religious rituals, and in cooking. It is no longer used as pesticide. In 1982, the US Food and Drug Administration restricted commercial products intended for medicinal use to contain <11% camphor.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
1.26 mM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Camphor ointment
Primary
CAMPHOR, EUCALYPTUS OIL AND MENTHOL - camphor, eucalyptus oil and menthol ointment CVS
Palliative
Tetramex Spray

Cmax

ValueDoseCo-administeredAnalytePopulation
41 ng/mL
374.4 mg single, topical
[NO STEREO] CAMPHOR, (-)-|[NO STEREO] CAMPHOR (SYNTHETIC)|[NO STEREO] CAMPHOR (NATURAL) plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
302 ng × h/mL
374.4 mg single, topical
[NO STEREO] CAMPHOR, (-)-|[NO STEREO] CAMPHOR (SYNTHETIC)|[NO STEREO] CAMPHOR (NATURAL) plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
6.5 h
374.4 mg single, topical
[NO STEREO] CAMPHOR, (-)-|[NO STEREO] CAMPHOR (SYNTHETIC)|[NO STEREO] CAMPHOR (NATURAL) plasma
Homo sapiens

Sourcing

PubMed

Sample Use Guides

In Vivo Use Guide
Dosing: Adult Cough: Inhalation: Inhale via vaporizer up to 3 times per day. Pain: Topical cream: Apply to affected area up to 4 times per day for 2 weeks. For maximum benefit, use daily for at least 2 weeks and continue to use daily as needed thereafter. Pruritus/Pain: Topical gel: Apply to affected area up to 3 to 4 times per day.
Route of Administration: Topical
In Vitro Use Guide
1 mM camphor partially inhibited the AITC (20 uM)-induced hTRPA1 current in HEK293T cells expressing hTRPA1.
Substance Class Chemical
Record UNII
N20HL7Q941
Record Status Validated (UNII)
Record Version