GLUCAMETACIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H27ClN2O8
Molecular Weight	518.943
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1)N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C2CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

InChIKey=XLVXAUNDHWERBM-IVGWJTKZSA-N

InChI=1S/C25H27ClN2O8/c1-13-17(10-22(32)27-19(11-29)23(33)24(34)21(31)12-30)18-9-16(36-2)7-8-20(18)28(13)25(35)14-3-5-15(26)6-4-14/h3-9,11,19,21,23-24,30-31,33-34H,10,12H2,1-2H3,(H,27,32)/t19-,21+,23+,24+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C25H27ClN2O8
Molecular Weight	518.943
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://armchairpatriot.com/Encyclopedias/Encyclopedia-Pharmaceutical%20Manufacturing%20(3rd%20edition)/15265_v02_05.pdf | https://www.ncbi.nlm.nih.gov/pubmed/6340973 | https://www.ncbi.nlm.nih.gov/pubmed/7001282

Glucametacin is a non-steroidal anti-inflammatory, analgesic, antipyretic agent. Glucametacin was compared with ketoprofen in a double-blind, crossover trial. The drugs were given in total daily doses of 420 mg glucametacin and 300 mg ketoprofen for 20 days to 30 patients with chronic arthropathies of an inflammatory or degenerative nature. Both drugs were well tolerated and resulted in significant improvements in a number of criteria of disease assessment. Although there were no significant differences between results seen with the two drugs, there appeared to be trends in favour of glucametacin in respect to both efficacy and tolerance.

Originator

Approval Year

PubMed

Title	Date	PubMed
Double-blind comparison of glucametacin and ketoprofen in chronic arthropathies.	1983	6340973
Further studies on glucametacin in rheumatoid arthritis and in other chronic types of rheumatism.	1981	6971729

Patents

Sample Use Guides

In Vivo Use Guide

Twenty-three patients with rheumatoid arthritis and 9 patients with other forms of rheumatic diseases were treated for 20 days with 420 mg glucametacin per day, given as three 140 mg capsules.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:57 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:57 GMT 2025`
Record UNII	N1EXE5EHAN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLUCAMETACIN

Official Name

English

GLUCAMETAN

Preferred Name

English

2-(2-(1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOL-3-YL)ACETAMIDO)-2-DEOXY-D-GLUCOSE

Common Name

English

GLUCAMETACIN [MI]

Common Name

English

GLUCAMETACINE

Common Name

English

glucametacin [INN]

Common Name

English

Glucametacin [WHO-DD]

Common Name

English

2-(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)-N-((3R,4R,5S,6R)-2,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3-YL)ACETAMIDE

Systematic Name

English

GLUCAMETACIN [MART.]

Common Name

English

2-(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)-N-((2R,3R,4S,5R)-3,4,5,6-TETRAHYDROXY-1-OXOHEXAN-2-YL)ACETAMIDE

Systematic Name

English

GLUCAMETHACIN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257