Parathyroid hormone (PTH) is an 84-amino acid peptide that regulates the function of osteoblasts and osteocytes and is secreted by the parathyroid gland in response to changes in the concentration of extracellular calcium. Parathyroid hormone is approved under the brand name NATPARA as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. It is also available for treatment of postmenopausal osteoporosis in many European countries. Parathyroid hormone is an activator of parathyroid hormone 2 receptor. In addition, was shown, that downregulation of Notch in osteoblasts and osteocytes may represent a mechanism contributing to the anabolic effects of parathyroid hormone in bone.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Initiate NATPARA ((parathyroid hormone) 50 mcg once daily as a subcutaneous njection in the thigh (alternate thigh very day). n patients using active forms of vitamine D decrease the dose of active vitamin D by 50%, if serum calcium is above 7.5 mg/dL. In patients using calcium supplements, maintain calcium supplement dose. Measure serum calcium concentration within 3 to 7 days.
Route of Administration:
Other
