Details
| Stereochemistry | MIXED |
| Molecular Formula | C28H31N5O |
| Molecular Weight | 453.5786 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=C2C(=CN([C@H]3C[C@H](CN4CCCC4)C3)C2=NC=N1)C5=CC=CC(OCC6=CC=CC=C6)=C5
InChI
InChIKey=LSFLAQVDISHMNB-AFARHQOCSA-N
InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)/t21-,23-
| Molecular Formula | C28H31N5O |
| Molecular Weight | 453.5786 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Sample Use Guides
NVP-ADW742 significantly inhibits the serum-stimulated cell proliferation in a variety of tumor cell lines in dose-dependent manner, with IC50 values of 0.1-0.5 μM for the multiple myeloma (MM) cell lines, and the antitumor effects on MM cells can not be overcome by the co-culture with BMSCs. In addition, NVP-ADW742 is active against MM cell lines.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:56:21 GMT 2023
by
admin
on
Sat Dec 16 10:56:21 GMT 2023
|
| Record UNII |
MXS2N5862L
|
| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID70431367
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9825149
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MXS2N5862L
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475488-23-4
Created by
admin on Sat Dec 16 10:56:21 GMT 2023 , Edited by admin on Sat Dec 16 10:56:21 GMT 2023
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ACTIVE MOIETY |
