VINLEUCINOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C51H69N5O9
Molecular Weight	896.1217
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)[C@@H](NC(=O)[C@]1(O)[C@@H]2N(C)C3=CC(OC)=C(C=C3[C@@]24CCN5CC=C[C@](CC)([C@@H]45)[C@H]1O)[C@]6(C[C@H]7CN(C[C@](O)(CC)C7)CCC8=C6NC9=C8C=CC=C9)C(=O)OC)[C@@H](C)CC

InChI

InChIKey=QSTPFUDHVVIGCL-MIESHYDTSA-N

InChI=1S/C51H69N5O9/c1-9-30(5)39(41(57)65-12-4)53-45(59)51(62)43-49(20-23-56-21-15-19-48(11-3,42(49)56)44(51)58)34-24-35(38(63-7)25-37(34)54(43)6)50(46(60)64-8)27-31-26-47(61,10-2)29-55(28-31)22-18-33-32-16-13-14-17-36(32)52-40(33)50/h13-17,19,24-25,30-31,39,42-44,52,58,61-62H,9-12,18,20-23,26-29H2,1-8H3,(H,53,59)/t30-,31-,39-,42-,43+,44+,47-,48+,49+,50-,51-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C51H69N5O9
Molecular Weight	896.1217
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8306418 | https://www.ncbi.nlm.nih.gov/pubmed/1524896

Vinleucinol (also known as vinblastine-isoleucinate or V-LEU) was developed as a vinca alkaloid derivative. This compound exhibited superior antitumor activity in malignant melanoma, small cell lung carcinoma, and breast cancer lines. Experiments on animals have shown that metabolite of vinleucinol was mainly responsible for the antitumor.

Approval Year

PubMed

Title	Date	PubMed
Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography.	1994	8306418
Comparative antitumour activity of vinblastine-isoleucinate and related vinca alkaloids in human tumour xenografts.	1992	1524896

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:12:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:12:20 GMT 2025`
Record UNII	MUJ5BW9BWR
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

(23(1S,2S))-4-DEACETYL-3-((1-CARBOXY-2-METHYLBUTYL)CARBAMOYL)-3-DE(METHOXYCARBONYL)VINCALEUKOBLASTINE, ETHYL ESTER

Preferred Name

English

VINLEUCINOL

Official Name

English

VINBLASTINE ISOLEUCINATE

Common Name

English

N-(O4-DEACETYL-23-VINBLASTINOYL) ETHYL L-ISOLEUCINATE

Common Name

English

vinleucinol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C932