Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H27N3O4S |
| Molecular Weight | 429.532 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(OCC2COC(C)(C)OC2)C(C)=C(C[S@@+]([O-])C3=NC4=C(N3)C=CC=C4)N=C1
InChI
InChIKey=DWDKHTXMLSZGDL-SSEXGKCCSA-N
InChI=1S/C22H27N3O4S/c1-14-9-23-19(13-30(26)21-24-17-7-5-6-8-18(17)25-21)15(2)20(14)27-10-16-11-28-22(3,4)29-12-16/h5-9,16H,10-13H2,1-4H3,(H,24,25)/t30-/m1/s1
| Molecular Formula | C22H27N3O4S |
| Molecular Weight | 429.532 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
E-3710 (Z-215) is a new proton pump inhibitor (PPI). E-3710 irreversibly inhibited H(+),K(+)-ATPase activity in pig gastric vesicles with an acidic internal environment. E-3710 is a long-acting inhibitor of gastric acid secretion and a promising novel therapy for acid-related diseases, such as gastroesophageal reflux disease. E-3710 is metabolized through oxidation, reduction and conjugation. Unchanged E-3710 was excreted in urine at trace levels but was not detected in faces. The major isozyme contributing to the oxidation of Z-215, including the formation of Z-215 sulphone, was CYP3A4. It is useful for treating gastroesophageal reflux disease in all CYP2C19 genotypes. E-3710 is in phase II clinical trial for the treatment of erosive esophagitis and gastro-esophageal reflux.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| E3710, a new proton pump inhibitor, with a long-lasting inhibitory effect on gastric acid secretion. | 2010 Aug |
|
| Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study. | 2018 |
|
| Pharmacokinetics and Pharmacodynamics of Azeloprazole Sodium, a Novel Proton Pump Inhibitor, in Healthy Japanese Volunteers. | 2018 Apr |
|
| Mass balance and metabolism of Z-215, a novel proton pump inhibitor, in healthy volunteers. | 2018 Oct |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:15:32 GMT 2023
by
admin
on
Sat Dec 16 02:15:32 GMT 2023
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| Record UNII |
MIR2G6L61B
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| Record Status |
Validated (UNII)
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17747247
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10426
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MIR2G6L61B
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C174711
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DTXSID50241865
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955095-45-1
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300000034083
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Azeloprazole
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SALT/SOLVATE -> PARENT |
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TARGET -> INHIBITOR |
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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