Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H30N2O3S |
| Molecular Weight | 426.572 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@]1([C@H]2CN(CC3(O)CC4=CC=CC=C4C3)C[C@@H]12)C5=CC(NS(C)(=O)=O)=CC=C5
InChI
InChIKey=ZBVPUFSKFGYNLC-FIDNPTQWSA-N
InChI=1S/C24H30N2O3S/c1-3-24(19-9-6-10-20(11-19)25-30(2,28)29)21-14-26(15-22(21)24)16-23(27)12-17-7-4-5-8-18(17)13-23/h4-11,21-22,25,27H,3,12-16H2,1-2H3/t21-,22+,24+
| Molecular Formula | C24H30N2O3S |
| Molecular Weight | 426.572 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
CP-866087 is a mu opioid receptor antagonist, discovered by Pfizer. The compound was able to antagonize the effect of morphine in a rodent tail flick assay and produced a dose-dependent decrease in alcohol intake in alcohol-preferring rats. The compound was investigated in clinical trials for the treatment of obesity, alcoholism and female sexual arousal disorder. In the later study, although improvements were seen with CP-866,087 in the key efficacy endpoints, there was no clinical treatment benefit over placebo.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:57:06 GMT 2025
by
admin
on
Mon Mar 31 20:57:06 GMT 2025
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| Record UNII |
MDH21334PI
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| Record Status |
Validated (UNII)
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| Record Version |
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MDH21334PI
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11154544
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DB12196
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845621-29-6
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admin on Mon Mar 31 20:57:06 GMT 2025 , Edited by admin on Mon Mar 31 20:57:06 GMT 2025
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NON-SPECIFIC STEREOCHEMISTRY | |||
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519052-02-9
Created by
admin on Mon Mar 31 20:57:06 GMT 2025 , Edited by admin on Mon Mar 31 20:57:06 GMT 2025
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ACTIVE MOIETY |
