UBIQUINOL is a reduced form of coenzyme Q10, a lipid-soluble molecule that consists of an aromatic ring and a 10-unit isoprenoid chain. It is naturally produced by the body. A significant increase in plasma CoQ10 status observed after supplementation in one study suggested that UBIQUINOL is a better supplemental form to enhance the CoQ10 status than ubiquinone (the oxidized form of Q10). UBIQUINOL has also been found to reduce oxidative stress induced by strenuous exercise. Oxidative stress is associated with aging and many chronic diseases, such as cardiovascular diseases, cancers, and cognitive decline. Ubiquinol has furthermore been shown to improve mitochondrial oxidative metabolism in the brain, and cognitive improvement was found as a result of Ubiquinol intake in chronic fatigue syndrome patients. UBIQUINOL is considered safe, but can have side effects such as upper abdominal pain, loss of appetite, nausea, diarrhea and headaches. CoQ10 might make blood-thinning drugs, such as warfarin (Coumadin, Jantoven), less effective. This could increase the risk of a blood clot.