BAY-1217389

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H24F5N5O3
Molecular Weight	561.5032
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(F)C(F)=C(OC2=NN3C(=CN=C3C(NCCC(F)(F)F)=C2)C4=CC=C(C(=O)NC5CC5)C(C)=C4)C=C1

InChI

InChIKey=WNEILUNVMHVMPH-UHFFFAOYSA-N

InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)

HIDE SMILES / InChI

Molecular Formula	C27H24F5N5O3
Molecular Weight	561.5032
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dual specificity protein kinase TTK 4 Target ID: CHEMBL3983 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26832791	Inhibitor 8504

C_max

Value	Dose	Co-administered	Analyte	Population
0.709 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.25 mg single, oral dose: 0.25 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
1.67 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.5 mg single, oral dose: 0.5 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
2.59 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
3.09 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
7.1 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
9.41 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	16 mg single, oral dose: 16 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
22 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	32 mg single, oral dose: 32 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
28.8 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	64 mg single, oral dose: 64 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
31.4 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
47.3 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
94.1 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	240 mg single, oral dose: 240 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
2.74 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.25 mg 2 times / day multiple, oral dose: 0.25 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
6.58 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.5 mg 2 times / day multiple, oral dose: 0.5 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
10.1 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	1 mg 2 times / day multiple, oral dose: 1 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
18.1 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	2 mg 2 times / day multiple, oral dose: 2 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
37.7 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	4 mg 2 times / day multiple, oral dose: 4 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
37.2 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	16 mg 2 times / day multiple, oral dose: 16 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
85.8 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	32 mg 2 times / day multiple, oral dose: 32 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
113 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	64 mg 2 times / day multiple, oral dose: 64 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
210.5 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	80 mg 2 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
137 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	120 mg 2 times / day multiple, oral dose: 120 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
630 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	240 mg 2 times / day multiple, oral dose: 240 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
2.81 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.25 mg 2 times / day multiple, oral dose: 0.25 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
4.78 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.5 mg 2 times / day multiple, oral dose: 0.5 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
8.66 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	1 mg 2 times / day multiple, oral dose: 1 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
16.4 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	2 mg 2 times / day multiple, oral dose: 2 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
30.5 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	4 mg 2 times / day multiple, oral dose: 4 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
38 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	16 mg 2 times / day multiple, oral dose: 16 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
76.2 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	32 mg 2 times / day multiple, oral dose: 32 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
111 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	64 mg 2 times / day multiple, oral dose: 64 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
213.5 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	80 mg 2 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
98.8 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	120 mg 2 times / day multiple, oral dose: 120 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
641 μg/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	240 mg 2 times / day multiple, oral dose: 240 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:

AUC

Value	Dose	Co-administered	Analyte	Population
4.41 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.25 mg single, oral dose: 0.25 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
11.6 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.5 mg single, oral dose: 0.5 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
16.2 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
21.2 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
44.1 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
53.7 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	16 mg single, oral dose: 16 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
138 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	32 mg single, oral dose: 32 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
172 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	64 mg single, oral dose: 64 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
212 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
303 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
672 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	240 mg single, oral dose: 240 mg route of administration: Oral experiment type: SINGLE co-administered:		BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
24.75 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.25 mg 2 times / day multiple, oral dose: 0.25 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
53.8 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.5 mg 2 times / day multiple, oral dose: 0.5 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
71.2 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	1 mg 2 times / day multiple, oral dose: 1 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
140 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	2 mg 2 times / day multiple, oral dose: 2 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
248 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	4 mg 2 times / day multiple, oral dose: 4 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
259 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	16 mg 2 times / day multiple, oral dose: 16 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
594 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	32 mg 2 times / day multiple, oral dose: 32 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
738 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	64 mg 2 times / day multiple, oral dose: 64 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
1630 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	80 mg 2 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
909 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	120 mg 2 times / day multiple, oral dose: 120 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
3710 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	240 mg 2 times / day multiple, oral dose: 240 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
21.6 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.25 mg 2 times / day multiple, oral dose: 0.25 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
46.68 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	0.5 mg 2 times / day multiple, oral dose: 0.5 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
71 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	1 mg 2 times / day multiple, oral dose: 1 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
145 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	2 mg 2 times / day multiple, oral dose: 2 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
212.5 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	4 mg 2 times / day multiple, oral dose: 4 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
349 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	16 mg 2 times / day multiple, oral dose: 16 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
659 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	32 mg 2 times / day multiple, oral dose: 32 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
921 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	64 mg 2 times / day multiple, oral dose: 64 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
2035 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	80 mg 2 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
783 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	120 mg 2 times / day multiple, oral dose: 120 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:
4830 μg × h/L CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	240 mg 2 times / day multiple, oral dose: 240 mg route of administration: Oral experiment type: MULTIPLE co-administered: PACLITAXEL	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status:

T_1/2

Value	Dose	Co-administered	Analyte	Population
4 day CLINICAL TRIAL https://pubmed.ncbi.nlm.nih.gov/34518310/	single, oral	PACLITAXEL	BAY-1217389 plasma	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:26:42 GMT 2025` Edited by `admin` on `Mon Mar 31 23:26:42 GMT 2025`
Record UNII	M964LB1114
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZAMIDE, N-CYCLOPROPYL-4-(6-(2,3-DIFLUORO-4-METHOXYPHENOXY)-8-((3,3,3-TRIFLUOROPROPYL)AMINO)IMIDAZO(1,2-B)PYRIDAZIN-3-YL)-2-METHYL-

Preferred Name

English

BAY-1217389

Code

English

Code System Code Type Description

ChEMBL

CHEMBL3544955