PGP-4008

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H23N3O
Molecular Weight	393.4803
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(CC1=CC=CC=C1)NC2=C3CCN(CC4=CC=CC=C4)C3=NC5=CC=CC=C25

InChI

InChIKey=HVIAKQBMYMKWII-UHFFFAOYSA-N

InChI=1S/C26H23N3O/c30-24(17-19-9-3-1-4-10-19)28-25-21-13-7-8-14-23(21)27-26-22(25)15-16-29(26)18-20-11-5-2-6-12-20/h1-14H,15-18H2,(H,27,28,30)

HIDE SMILES / InChI

Molecular Formula	C26H23N3O
Molecular Weight	393.4803
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
P-glycoprotein 1 54 Target ID: CHEMBL4302 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19262372	Inhibitor 8297

PubMed

Title	Date	PubMed
Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008.	2003	14552591

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:07:01 GMT 2023` Edited by `admin` on `Sat Dec 16 11:07:01 GMT 2023`
Record UNII	M7JJR8HX5D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PGP-4008

Code

English

N-(2,3-DIHYDRO-1-(PHENYLMETHYL)-1H-PYRROLO(2,3-B)QUINOLIN-4-YL)BENZENEACETAMIDE

Systematic Name

English

BENZENEACETAMIDE, N-(2,3-DIHYDRO-1-(PHENYLMETHYL)-1H-PYRROLO(2,3-B)QUINOLIN-4-YL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

9821937

Created by admin on Sat Dec 16 11:07:01 GMT 2023 , Edited by admin on Sat Dec 16 11:07:01 GMT 2023

PRIMARY

CAS

365565-02-2

Created by admin on Sat Dec 16 11:07:01 GMT 2023 , Edited by admin on Sat Dec 16 11:07:01 GMT 2023

PRIMARY

FDA UNII

M7JJR8HX5D

Created by admin on Sat Dec 16 11:07:01 GMT 2023 , Edited by admin on Sat Dec 16 11:07:01 GMT 2023

PRIMARY

Related Record Type Details


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TARGET -> INHIBITOR

Comments:

Selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1

Amount:

Related Record Type Details


					M7JJR8HX5D

PGP-4008

ACTIVE MOIETY