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Details

Stereochemistry ACHIRAL
Molecular Formula C21H25N3O3S
Molecular Weight 399.507
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIPAZETHATE

SMILES

O=C(OCCOCCN1CCCCC1)N2C3=C(SC4=C2N=CC=C4)C=CC=C3

InChI

InChIKey=DTVJXCOMJLLMAK-UHFFFAOYSA-N
InChI=1S/C21H25N3O3S/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24/h2-3,6-10H,1,4-5,11-16H2

HIDE SMILES / InChI
Molecular Formula C21H25N3O3S
Molecular Weight 399.507
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

PIPAZETHATE is a non-narcotic oral antitussive agent. It acts centrally on the medullary cough center and is used for the treatment of cough.

CNS Activity

Approval Year

1962
69
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Theratuss

Approved Use

Pipazethate is a centrally acting antitussive drug that also has bronchodilatory and local anesthetic activities.

Launch Date

1962
Doses

Doses

DosePopulationAdverse events​
40 mg/mL single, oral
Overdose
Dose: 40 mg/mL
Route: oral
Route: single
Dose: 40 mg/mL
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
healthy, 32 months
n = 1
Health Status: healthy
Age Group: 32 months
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
Other AEs: Tonic-clonic seizures, Coma...
Other AEs:
Tonic-clonic seizures (grade 5, 1 patient)
Coma (grade 5, 1 patient)
Respiratory insufficiency (grade 5, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
AEs

AEs

AESignificanceDosePopulation
Coma grade 5, 1 patient
40 mg/mL single, oral
Overdose
Dose: 40 mg/mL
Route: oral
Route: single
Dose: 40 mg/mL
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
healthy, 32 months
n = 1
Health Status: healthy
Age Group: 32 months
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
Respiratory insufficiency grade 5, 1 patient
40 mg/mL single, oral
Overdose
Dose: 40 mg/mL
Route: oral
Route: single
Dose: 40 mg/mL
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
healthy, 32 months
n = 1
Health Status: healthy
Age Group: 32 months
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
Tonic-clonic seizures grade 5, 1 patient
40 mg/mL single, oral
Overdose
Dose: 40 mg/mL
Route: oral
Route: single
Dose: 40 mg/mL
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
healthy, 32 months
n = 1
Health Status: healthy
Age Group: 32 months
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7180211
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY540919
https://www.001chemical.com/chem/2167-85-3
ABI Chem
AC1L2KDQ
ABI Chem
AC1Q68DF
Alfa Chemistry
ACM14056678
BOC Sciences
1518261
BOC Sciences
2167-85-3
ChemMol
99053672
http://www.chemmol.com/chemmol/99053672.html
Compound Cloud
22425
Hangzhou Yuhao Chemical Technology
RT8539
MolPort
MolPort-006-113-900
https://www.molport.com/shop/molecule-link/MolPort-006-113-900
Molcore
MC540919
https://www.molcore.com/product/2167-85-3
MuseChem
I008771
MuseChem
R055706
NCI Plated 2007
106961
NovoSeek
22425
Smolecule
S539724
http://www.smolecule.com/products/s539724
THE BioTek
bt-278393
https://www.thebiotek.com/product/inhibitors/bt-278393
Toronto Research Chemicals
F591410
Toronto Research Chemicals
P475700
ZINC
ZINC000001698105
http://zinc15.docking.org/substances/ZINC000001698105
eMolecules
110068230
eMolecules
300635622
eMolecules
43551997
eNovation Chemicals
D674615
https://www.enovationchem.com/ProductDetails.asp?ProductID=D674615
PubMed

PubMed

TitleDatePubMed
Flow injection potentiometric determination of pipazethate hydrochloride.
2001 Jan
Spectrophotometric determination of some anti-tussive and anti-spasmodic drugs through ion-pair complex formation with thiocyanate and cobalt(II) or molybdenum(V).
2007 Apr
Spectrophotometric determination of pipazethate hydrochloride in pure form and in pharmaceutical formulations.
2007 May-Jun
Flow injection potentiometric assay of hexoprenaline in its pure state, pharmaceutical preparations, and biological samples.
2008
Spectrophotometric determination of etodolac in pure form and pharmaceutical formulations.
2008 Apr 14
Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.
2010
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:01:44 GMT 2023
Edited
by admin
on Fri Dec 15 15:01:44 GMT 2023
Record UNII
M5EK1T5V2L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PIPAZETHATE
MI   USAN  
USAN  
Official Name English
SK&F 70230-A
Code English
Pipazetate [WHO-DD]
Common Name English
10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-CARBOXYLIC ACID, 2-(2-(1-PIPERIDINYL)ETHOXY)ETHYL ESTER
Common Name English
2-(2-Piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
Systematic Name English
PIPAZETATE [MART.]
Common Name English
PIPAZETHATE [USAN]
Common Name English
pipazetate [INN]
Common Name English
PIPAZETHATE [MI]
Common Name English
D-254
Code English
SQ 15,874
Code English
SQ-15874
Code English
PIPAZETATE
INN   MART.   WHO-DD  
INN  
Official Name English
SK&F-70230-A
Code English
Classification Tree Code System Code
WHO-ATC R05DB11
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
WHO-VATC QR05DB11
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
NCI_THESAURUS C66917
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
Code System Code Type Description
SMS_ID
100000081981
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
WIKIPEDIA
PIPAZETATE
Created by admin on Fri Dec 15 15:01:45 GMT 2023 , Edited by admin on Fri Dec 15 15:01:45 GMT 2023
PRIMARY
MESH
C016064
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
CAS
2167-85-3
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
FDA UNII
M5EK1T5V2L
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
DRUG BANK
DB08796
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
PUBCHEM
22425
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
MERCK INDEX
m8839
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C82252
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
ECHA (EC/EINECS)
218-508-8
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104900
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
INN
1124
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
EVMPD
SUB09861MIG
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
DRUG CENTRAL
2182
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
EPA CompTox
DTXSID40176056
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY
RXCUI
33740
Created by admin on Fri Dec 15 15:01:44 GMT 2023 , Edited by admin on Fri Dec 15 15:01:44 GMT 2023
PRIMARY RxNorm
Related Record Type Details
Structure of PIPAZETHATE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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