Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C24H24ClNO3 |
| Molecular Weight | 409.905 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C)(OC1=CC=C(CC2=CC=C(Cl)C=C2)C=C1)C(=O)OCC3=CC=CN=C3
InChI
InChIKey=VKNSAVOURPMBRN-UHFFFAOYSA-N
InChI=1S/C24H24ClNO3/c1-3-24(2,23(27)28-17-20-5-4-14-26-16-20)29-22-12-8-19(9-13-22)15-18-6-10-21(25)11-7-18/h4-14,16H,3,15,17H2,1-2H3
| Molecular Formula | C24H24ClNO3 |
| Molecular Weight | 409.905 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Eniclobrate (Sgd 33374), a diphenylmethane derivative, is a lipid-lowering compound. In rodents, eniclobrate lower serum and liver cholesterol levels and reduced the percentage of esterified cholesterol present in the serum but raised liver triglyceride levels. In a clinical trial for the treatment of hyperlipidemia type IIa and type IIb eniclobrate effectively reduced LDL-cholesterol in type IIa, however, there was a remarkable increase in HDL-cholesterol in both types of hyperlipidemia.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Beclobrate and eniclobrate hydrochloride, new diphenylmethane derivatives as agents for lowering cholesterol and triglyceride levels. Part I: Synthesis and consideration of structure-activity relationships (author's transl)]. | 1979 |
|
| Lipid-lowering effect of the new drugs eniclobrate and beclobrate in patients with hyperlipidemia type II a and type II b. | 1981 |
|
| Influence of beclobrate and eniclobrate on cholesterol metabolism in rats. | 1983 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:30:20 GMT 2023
by
admin
on
Fri Dec 15 16:30:20 GMT 2023
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| Record UNII |
M469UFX48N
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| Record Status |
Validated (UNII)
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| Record Version |
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Common Name | English |
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NCI_THESAURUS |
C29703
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C72992
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81126-88-7
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43387
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4250
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C021021
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100000080230
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CHEMBL2106104
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SUB06532MIG
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M469UFX48N
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
