ETHAMIVAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H17NO3
Molecular Weight	223.2683
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCN(CC)C(=O)C1=CC=C(O)C(OC)=C1

InChI

InChIKey=BQJODPIMMWWMFC-UHFFFAOYSA-N

InChI=1S/C12H17NO3/c1-4-13(5-2)12(15)9-6-7-10(14)11(8-9)16-3/h6-8,14H,4-5H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C12H17NO3
Molecular Weight	223.2683
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Ethamivan or etamivan, a respiratory stimulant was used in pulmonary emphysema.

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pulmonary emphysema 6	Primary		Not Provided 511	Unknown
Respiratory depression 7	Primary		Approved 8,583	Emivan

Doses

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Dose	Population	Adverse events
10000 mg multiple, intravenous Highest studied dose	unhealthy, 21 years
500 mg single, oral Highest studied dose	unhealthy
2.5 mg/kg single, intravenous Highest studied dose	unhealthy	Other AEs: Nausea, Vomiting...

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AEs

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AE	Significance	Dose	Population
Ear buzzing	1 patient	2.5 mg/kg single, intravenous Highest studied dose	unhealthy
Pruritus	1 patient	2.5 mg/kg single, intravenous Highest studied dose	unhealthy
Visual hallucinations	1 patient	2.5 mg/kg single, intravenous Highest studied dose	unhealthy
Vomiting	1 patient	2.5 mg/kg single, intravenous Highest studied dose	unhealthy
Dizziness	2 patients	2.5 mg/kg single, intravenous Highest studied dose	unhealthy

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
001 Chemical	DY547425	https://www.001chemical.com/chem/304-84-7
3B Scientific (Wuhan) Corp	3B3-021459	http://www.3bsc.com/index/pro_info.php?id=43535
AA Blocks	AA002ZX3	https://www.aablocks.com/goods/Goods/detail?id=AA002ZX3
AbMole Bioscience	M2688	http://www.abmole.com/products/ethamivan.html
AHH Chemical co.,ltd	MT-60342	http://www.ahhchemical.com/product/MT-60342.html

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PubMed

PubMed

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Title	Date	PubMed
Effect of ethamivan on alveolar ventilation in patients with chronic lung disease.	1962 Dec 20	13974643
Respiratory depression in the coma of myxedema: treatment with ethamivan intravenously.	1969 Oct	4390496

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Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	M44O63YPV9
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

ETHAMIVAN

Official Name

English

ETAMIVAN

Preferred Name

English

N,N-Diethylvanillamide

Systematic Name

English

ETAMIVAN [MART.]

Common Name

English

VANDID

Brand Name

English

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Classification Tree

Code System

Code

Agent Affecting Nervous System

NCI_THESAURUS

C47795

Respiratory stimulants

WHO-ATC

R07AB04

Respiratory stimulants

WHO-VATC

QR07AB04

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Code System

Code

Type

Description

DRUG CENTRAL

1074

PRIMARY

NSC

406087

PRIMARY

DRUG BANK

DB08989

PRIMARY

INN

1174

PRIMARY

WIKIPEDIA

Etamivan

PRIMARY

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Related Record

Type

Details


					M44O63YPV9

ETHAMIVAN

ACTIVE MOIETY

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SMILES

InChI

Description<div class="info-popup-container"><div><span class="pop-sub-key ">Sources:&nbsp;</span><span class="pop-sub-val"><span class="ext-link"><a target="_self" href="https://www.ncbi.nlm.nih.gov/pubmed/4387399">https://www.ncbi.nlm.nih.gov/pubmed/4387399</a></span></span></div></div>

Approval Year

Conditions

Doses

AEs

Sourcing

PubMed

Sample Use Guides

Description