MK-7145

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H30N2O6
Molecular Weight	466.5262
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C2COC(=O)C2=CC=C1[C@@H](O)CN3CCN(C[C@H](O)C4=C(C)C5=C(C=C4)C(=O)OC5)CC3

InChI

InChIKey=OCKGFTQIICXDQW-ZEQRLZLVSA-N

InChI=1S/C26H30N2O6/c1-15-17(3-5-19-21(15)13-33-25(19)31)23(29)11-27-7-9-28(10-8-27)12-24(30)18-4-6-20-22(16(18)2)14-34-26(20)32/h3-6,23-24,29-30H,7-14H2,1-2H3/t23-,24-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H30N2O6
Molecular Weight	466.5262
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27437080 | https://www.ncbi.nlm.nih.gov/pubmed/27432892 | https://clinicaltrials.gov/ct2/show/NCT01370655

MK-7145 is a piperazine derivative patented by Merck Sharp & Dohme Corporation as the renal outer medullary potassium channel inhibitor useful for the treatment of hypertension and heart failure. In preclinical studies, MK-7145 shows selectivity against other cardiac ion channels such as Cav1.2, Nav1.5, and Kir2.1, Kir2.3, Kir4.1, or Kir7.1. In 2011 MK-7145 was studied in phase I clinical trials but no further development reports were published.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.	2016-07-14	27437080

Patents

Sample Use Guides

In Vivo Use Guide

MK-7145 3 mg then 3 mg MK-7145 4 hours later, daily for 4 weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:16:55 GMT 2025` Edited by `admin` on `Mon Mar 31 21:16:55 GMT 2025`
Record UNII	M371870BYL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MK-7145

Common Name

English

1(3H)-ISOBENZOFURANONE, 5,5'-(1,4-PIPERAZINEDIYLBIS((1R)-1-HYDROXY-2,1-ETHANEDIYL))BIS(4-METHYL-

Preferred Name

English

5,5'-((1R,1'R)-PIPERAZINE-1,4-DIYLBIS(1-HYDROXYETHANE-2,1-DIYL))BIS(4-METHYLISOBENZOFURAN-1(3H)-ONE)

Systematic Name

English

Code System Code Type Description

FDA UNII

M371870BYL