U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H40N8O7
Molecular Weight 516.5917
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THYMOCARTIN

SMILES

CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(O)=O

InChI

InChIKey=COIXXKVZEXZCLU-YXWQFLTLSA-N
InChI=1S/C21H40N8O7/c1-11(2)16(20(35)36)29-19(34)14(10-15(30)31)28-18(33)13(7-3-4-8-22)27-17(32)12(23)6-5-9-26-21(24)25/h11-14,16H,3-10,22-23H2,1-2H3,(H,27,32)(H,28,33)(H,29,34)(H,30,31)(H,35,36)(H4,24,25,26)/t12-,13-,14-,16-/m0/s1

HIDE SMILES / InChI

Molecular Formula C21H40N8O7
Molecular Weight 516.5917
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Thymocartin (also known as T4 and RGH-0206) is a protected synthetic tetrapeptide patented by Hungarian multinational pharmaceutical and biotechnology company Gedeon Richter Plc. (Richter, Gedeon, Vegyeszeti Gyar Rt) as an immunomodulating agent. In preclinical models, Thymocartin shows to exert similar immunomodulatory activities to thymopoietin affecting both humoral and cellular responses. In skin graft mouse model Thymocartin increases the number of splenic T cells and restored the rejection capacity of thymectomized C57Bl mice. In chronic 28-days i.v. toxicity studies in dogs no adverse reaction has been found. The low toxicity of Thymocartin is probably attributable to their short half-life as the half-life of the Thymocartin is less than 3 min in humans.

Approval Year

PubMed

PubMed

TitleDatePubMed
The effect of TP-5 and its analogs on skin grafts in mice.
1985
Investigation Into Efficiency of a Novel Glycol Chitosan-Bestatin Conjugate to Protect Thymopoietin Oligopeptides From Enzymatic Degradation.
2016 Feb
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:30:45 GMT 2023
Edited
by admin
on Fri Dec 15 15:30:45 GMT 2023
Record UNII
M0H0SK3AD5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THYMOCARTIN
INN  
INN  
Official Name English
H-ARG-LYS-ASP-VAL-OH
Common Name English
N-(N-(N2-L-ARGINYL-L-LYSYL)-L-.ALPHA.-ASPARTYL)-L-VALINE
Systematic Name English
thymocartin [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C548
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
Code System Code Type Description
FDA UNII
M0H0SK3AD5
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
NCI_THESAURUS
C90959
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
INN
6308
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
PUBCHEM
3033954
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
CAS
85466-18-8
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
MESH
C045802
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID20234688
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
SMS_ID
100000082150
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
EVMPD
SUB10991MIG
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104516
Created by admin on Fri Dec 15 15:30:45 GMT 2023 , Edited by admin on Fri Dec 15 15:30:45 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY