Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H18N2O4 |
| Molecular Weight | 314.3358 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)C1(CC1)OC(=O)C2=CN=CN2[C@H](C)C3=CC=CC=C3
InChI
InChIKey=DRAFVCKNYNQOKR-GFCCVEGCSA-N
InChI=1S/C17H18N2O4/c1-12(13-6-4-3-5-7-13)19-11-18-10-14(19)15(20)23-17(8-9-17)16(21)22-2/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1
| Molecular Formula | C17H18N2O4 |
| Molecular Weight | 314.3358 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
MDCO 700 (formerly ABP 700) is hypnosedative and anaesthetic agent that was being developed by The Medicines Company for the induction of general anesthesia and procedural sedation. It is a positive allosteric modulator of the GABAA receptor. It is a second generation analogue of etomidate, developed to retain etomidate's beneficial haemodynamic and respiratory profile but diminishing its suppression of the adrenocortical axis. Infusions of ABP-700 showed a dose-dependent hypnotic effect, and did not cause severe hypotension, severe respiratory depression, or adrenocortical suppression. The drug development for anaesthesia has been discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects. | 2018-06 |
|
| Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs. | 2014-12 |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: ABP-700 as a 7 min infusion is safe and generally well tolerated. Infusion rates of 100 ug/kg/minand aboveare associated with drug-induced unconsciousnesswith goodpreservation of spontaneous breathing. https://www.isaponline.org/application/files/1614/7976/4265/03_Meier_ISAP.pdf
Five cohorts involving 40 subjects received increasing infusion doses of ABP-700, propofol 60 ug kg-1 min-1 or placebo.
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
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LZ0835OW2M
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