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Details

Stereochemistry ACHIRAL
Molecular Formula C19H20FN5O4
Molecular Weight 401.3916
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ZABOFLOXACIN

SMILES

CO\N=C1/CN(CC12CNC2)C3=NC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(O)=O

InChI

InChIKey=ZNPOCLHDJCAZAH-OEAKJJBVSA-N
InChI=1S/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)/b23-14+

HIDE SMILES / InChI

Molecular Formula C19H20FN5O4
Molecular Weight 401.3916
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Zabofloxacin (also known as DW-224a), a fluoroquinolone antibiotic agent, is a dual inhibitor of both DNA gyrase and topoisomerase IV of Streptococcus pneumonia. Zabofloxacin successfully has completed phase III clinical trial in patients with acute bacterial exacerbation of the chronic obstructive pulmonary disease. In addition, in May 2012, IASO terminated phase II trial of oral zabofloxacin capsules in patients with moderate-to-severe community-acquired pneumonia due to financial considerations.

Approval Year

PubMed

PubMed

TitleDatePubMed
Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent.
2004 Nov
Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains.
2008 Sep
New treatment options for lower respiratory tract infections.
2017 Sep
Patents

Sample Use Guides

Zabofloxacin 367mg tablet P.O. once daily for 5days and then Placebo P.O. once daily for 2days
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:54:01 UTC 2023
Edited
by admin
on Sat Dec 16 16:54:01 UTC 2023
Record UNII
LV66BA6V2G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZABOFLOXACIN
INN   WHO-DD  
INN  
Official Name English
Zabofloxacin [WHO-DD]
Common Name English
1-CYCLOPROPYL-6-FLUORO-7-(8-(METHOXYIMINO)-2,6-DIAZASPIRO(3.4)OCTAN-6-YL)-4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID
Systematic Name English
zabofloxacin [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C795
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
Code System Code Type Description
FDA UNII
LV66BA6V2G
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
DRUG BANK
DB12479
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
NCI_THESAURUS
C82232
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
WIKIPEDIA
Zabofloxacin
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
MESH
C480202
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
DRUG CENTRAL
5249
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
INN
8594
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
CAS
219680-11-2
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
SMS_ID
100000182642
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
EVMPD
SUB196891
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
ChEMBL
CHEMBL2107811
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
PUBCHEM
10388396
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
EPA CompTox
DTXSID10870251
Created by admin on Sat Dec 16 16:54:03 UTC 2023 , Edited by admin on Sat Dec 16 16:54:03 UTC 2023
PRIMARY
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