U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

2018
425
Substance Class Protein
Created
by admin
on Mon Mar 31 20:32:43 GMT 2025
Edited
by admin
on Mon Mar 31 20:32:43 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
LT369U66CE
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
IBALIZUMAB, LICENSE HOLDER UNSPECIFIED
Preferred Name English
IBALIZUMAB
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
TNX-355
Code English
IMMUNOGLOBULIN G4, ANTI-(HUMAN CD4 (ANTIGEN)) (HUMAN-MOUSE MONOCLONAL 5A8 .GAMMA.4-CHAIN), DISULPHIDE WITH HUMAN-MOUSE MONOCLONAL 5A8 .KAPPA.-CHAIN, DIMER
Common Name English
ibalizumab [INN]
Common Name English
Ibalizumab-uiyk [WHO-DD]
Common Name English
IMMUNOGLOBULIN G4, ANTI-(HUMAN CD4 (ANTIGEN)) (HUMAN-MOUSE MONOCLONAL 5A8 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL 5A8 .KAPPA.-CHAIN, DIMER
Common Name English
Ibalizumab [WHO-DD]
Common Name English
IBALIZUMAB [USAN]
Common Name English
IBALIZUMAB [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC J05AX23
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
NCI_THESAURUS C20401
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
FDA ORPHAN DRUG 70692
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
FDA ORPHAN DRUG 321910
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
Code System Code Type Description
WIKIPEDIA
Hexamethylphosphoramide
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
EVMPD
SUB130719
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
ALTERNATIVE
FDA UNII
LT369U66CE
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
SMS_ID
100000168847
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
DRUG BANK
DB12698
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
EVMPD
SUB182421
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
ChEMBL
CHEMBL1743029
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
DAILYMED
LT369U66CE
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
RXCUI
2043313
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
ALTERNATIVE
LACTMED
Ibalizumab
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
MERCK INDEX
m12068
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
DRUG CENTRAL
5279
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
NCI_THESAURUS
C88612
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
CAS
680188-33-4
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
RXCUI
2043283
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
INN
8818
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
EPA CompTox
DTXSID601028049
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
USAN
SS-01
Created by admin on Mon Mar 31 20:32:43 GMT 2025 , Edited by admin on Mon Mar 31 20:32:43 GMT 2025
PRIMARY
From To
1_22 1_96
1_136 3_219
1_149 1_205
1_228 2_228
1_231 2_231
1_263 1_323
1_369 1_427
2_22 2_96
2_136 4_219
2_149 2_205
2_263 2_323
2_369 2_427
3_23 3_94
3_139 3_199
4_23 4_94
4_139 4_199
Related Record Type Details
T-CELL SURFACE GLYCOPROTEIN CD4
TARGET -> INHIBITOR
Blocks HIV infection. Used against MDR HIV Strains
IBALIZUMAB-UIYK [PURPLE BOOK CDER]
INNOVATOR->PARENT
IBALIZUMAB-UIYK [PURPLE BOOK CDER]
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
IBALIZUMAB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Molecular Formula CHEMICAL
MOL_WEIGHT:ESTIMATED CHEMICAL
Biological Half-life PHARMACOKINETIC
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966