SURICLONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H20ClN5O3S2
Molecular Weight	477.988
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C(=O)OC2N(C(=O)C3=C2SCCS3)C4=CC=C5C=CC(Cl)=NC5=N4

InChI

InChIKey=RMXOUBDDDQUBKD-UHFFFAOYSA-N

InChI=1S/C20H20ClN5O3S2/c1-24-6-8-25(9-7-24)20(28)29-19-16-15(30-10-11-31-16)18(27)26(19)14-5-3-12-2-4-13(21)22-17(12)23-14/h2-5,19H,6-11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C20H20ClN5O3S2
Molecular Weight	477.988
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7910470 | https://www.ncbi.nlm.nih.gov/pubmed/7910470 | https://www.ncbi.nlm.nih.gov/pubmed/3602309

Suriclone is a dithiinopyrrole derivative patented by Rhone-Poulenc S. A. as a sedative and anxiolytic drug. The mechanism of action by which suriclone produces it's sedative and anxiolytic effects is by modulating GABAA receptors, although suriclone is more subtype-selective than most benzodiazepines. In clinical trials, Suriclone shows a significant anxiolytic effect. The most common adverse reaction was dizziness.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry.	1994 Feb	7910470
Objective markers of drug effects on brain function from recordings of scalp potential in healthy volunteers.	2002 Dec	22033496
Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.	2010 Nov 3	21047414

Patents

Sample Use Guides

In Vivo Use Guide

0.1, 0.2 and 0.4 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:19:49 UTC 2023` Edited by `admin` on `Fri Dec 15 18:19:49 UTC 2023`
Record UNII	LNC9G689VR
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SURICLONE

Official Name

English

RP-31264

Code

English

SURICLONE [MI]

Common Name

English

RP 31264

Code

English

1-PIPERAZINECARBOXYLIC ACID, 4-METHYL-, 6-(7-CHLORO-1,8-NAPHTHYRIDIN-2-YL)-2,3,6,7-TETRAHYDRO-7-OXO-5H-1,4-DITHIINO(2,3-C)PYRROL-5-YL ESTER

Systematic Name

English

CELEXANE

Brand Name

English

SURIL

Brand Name

English

SURICLONE [MART.]

Common Name

English

suriclone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197