SURICLONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H20ClN5O3S2
Molecular Weight	477.988
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C(=O)OC2N(C(=O)C3=C2SCCS3)C4=CC=C5C=CC(Cl)=NC5=N4

InChI

InChIKey=RMXOUBDDDQUBKD-UHFFFAOYSA-N

InChI=1S/C20H20ClN5O3S2/c1-24-6-8-25(9-7-24)20(28)29-19-16-15(30-10-11-31-16)18(27)26(19)14-5-3-12-2-4-13(21)22-17(12)23-14/h2-5,19H,6-11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C20H20ClN5O3S2
Molecular Weight	477.988
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7910470 | https://www.ncbi.nlm.nih.gov/pubmed/7910470 | https://www.ncbi.nlm.nih.gov/pubmed/3602309

Suriclone is a dithiinopyrrole derivative patented by Rhone-Poulenc S. A. as a sedative and anxiolytic drug. The mechanism of action by which suriclone produces it's sedative and anxiolytic effects is by modulating GABAA receptors, although suriclone is more subtype-selective than most benzodiazepines. In clinical trials, Suriclone shows a significant anxiolytic effect. The most common adverse reaction was dizziness.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.	2010-11-03	21047414
Objective markers of drug effects on brain function from recordings of scalp potential in healthy volunteers.	2002-12	22033496
Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry.	1994-02	7910470

Patents

Sample Use Guides

In Vivo Use Guide

0.1, 0.2 and 0.4 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:10:26 GMT 2025` Edited by `admin` on `Mon Mar 31 19:10:26 GMT 2025`
Record UNII	LNC9G689VR
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CELEXANE

Preferred Name

English

SURICLONE

Official Name

English

RP-31264

Code

English

SURICLONE [MI]

Common Name

English

RP 31264

Code

English

1-PIPERAZINECARBOXYLIC ACID, 4-METHYL-, 6-(7-CHLORO-1,8-NAPHTHYRIDIN-2-YL)-2,3,6,7-TETRAHYDRO-7-OXO-5H-1,4-DITHIINO(2,3-C)PYRROL-5-YL ESTER

Systematic Name

English

SURIL

Brand Name

English

SURICLONE [MART.]

Common Name

English

suriclone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197