Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H15F3N4 |
| Molecular Weight | 332.323 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC2=C(N1)N=CN=C2N[C@@H]3CCCC4=C3C=CC=C4
InChI
InChIKey=JOIONRWKOGDQOG-CYBMUJFWSA-N
InChI=1S/C17H15F3N4/c18-17(19,20)14-8-12-15(21-9-22-16(12)24-14)23-13-7-3-5-10-4-1-2-6-11(10)13/h1-2,4,6,8-9,13H,3,5,7H2,(H2,21,22,23,24)/t13-/m1/s1
| Molecular Formula | C17H15F3N4 |
| Molecular Weight | 332.323 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:19:47 GMT 2023
by
admin
on
Sat Dec 16 20:19:47 GMT 2023
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| Record UNII |
LN62PXZ9FP
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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2499962-58-0
Created by
admin on Sat Dec 16 20:19:48 GMT 2023 , Edited by admin on Sat Dec 16 20:19:48 GMT 2023
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LN62PXZ9FP
Created by
admin on Sat Dec 16 20:19:48 GMT 2023 , Edited by admin on Sat Dec 16 20:19:48 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET -> ACTIVATOR |
MTK458 binds PINK1 directly and stabilizes it in an active conformation. Indeed, PINK1 activation was found to be caused directly by MTK458 and not its metabolite(s).
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