MTK-458

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H15F3N4
Molecular Weight	332.323
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C1=CC2=C(N[C@@H]3CCCC4=C3C=CC=C4)N=CN=C2N1

InChI

InChIKey=JOIONRWKOGDQOG-CYBMUJFWSA-N

InChI=1S/C17H15F3N4/c18-17(19,20)14-8-12-15(21-9-22-16(12)24-14)23-13-7-3-5-10-4-1-2-6-11(10)13/h1-2,4,6,8-9,13H,3,5,7H2,(H2,21,22,23,24)/t13-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H15F3N4
Molecular Weight	332.323
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 18:57:32 GMT 2025` Edited by `admin` on `Wed Apr 02 18:57:32 GMT 2025`
Record UNII	LN62PXZ9FP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MTK458

Preferred Name

English

MTK-458

Common Name

English

N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Systematic Name

English

Mitophagy activator 1

Common Name

English

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-

Common Name

English

Code System Code Type Description

CAS

2499962-58-0

Created by admin on Wed Apr 02 18:57:32 GMT 2025 , Edited by admin on Wed Apr 02 18:57:32 GMT 2025

PRIMARY

PUBCHEM

155187445

Created by admin on Wed Apr 02 18:57:32 GMT 2025 , Edited by admin on Wed Apr 02 18:57:32 GMT 2025

PRIMARY

FDA UNII

LN62PXZ9FP

Created by admin on Wed Apr 02 18:57:32 GMT 2025 , Edited by admin on Wed Apr 02 18:57:32 GMT 2025

PRIMARY

Related Record Type Details


					22DXZ2U99R

SERINE/THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL

TARGET -> ACTIVATOR

Comments:

MTK458 binds PINK1 directly and stabilizes it in an active conformation. Indeed, PINK1 activation was found to be caused directly by MTK458 and not its metabolite(s).

Amount: