SERINE/THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 14:05:03 GMT 2025` Edited by `admin` on `Wed Apr 02 14:05:03 GMT 2025`
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	22DXZ2U99R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PINK1 expressed protein

Preferred Name

English

SERINE/THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL

Common Name

English

PTEN-induced putative kinase protein 1

Common Name

English

Code System Code Type Description

UNIPROT

Q9BXM7

Created by admin on Wed Apr 02 14:05:03 GMT 2025 , Edited by admin on Wed Apr 02 14:05:03 GMT 2025

PRIMARY

FDA UNII

22DXZ2U99R

Created by admin on Wed Apr 02 14:05:03 GMT 2025 , Edited by admin on Wed Apr 02 14:05:03 GMT 2025

PRIMARY

Related Record Type Details


					LN62PXZ9FP

MTK-458

ACTIVATOR -> TARGET

Comments:

MTK458 binds PINK1 directly and stabilizes it in an active conformation. Indeed, PINK1 activation was found to be caused directly by MTK458 and not its metabolite(s).

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_151] [1_325]	SITE_SPECIFIC	S		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL