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Details

Stereochemistry ACHIRAL
Molecular Formula 2Al.3O
Molecular Weight 101.9613
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALUMINUM OXIDE

SMILES

[O--].[O--].[O--].[Al+3].[Al+3]

InChI

InChIKey=PNEYBMLMFCGWSK-UHFFFAOYSA-N
InChI=1S/2Al.3O/q2*+3;3*-2

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Al
Molecular Weight 26.9815
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/algeldrate.html | https://www.ncbi.nlm.nih.gov/pubmed/18362170 | https://www.ncbi.nlm.nih.gov/pubmed/12222737 | https://www.ncbi.nlm.nih.gov/pubmed/9115023 | https://www.ncbi.nlm.nih.gov/pubmed/15479434

Algeldrate (Aluminium hydroxide) is the amphoteric inorganic compound used as an antacid in the treatment of Duodenal, Peptic and Stomach Ulcer and some other conditions. Aluminium hydroxide is preferred over other alternatives such as sodium bicarbonate because Al(OH)3, being insoluble, does not increase the pH of stomach above 7 and hence, does not trigger secretion of excess acid by the stomach. Brand names include Alu-Cap, Aludrox, Gaviscon or Pepsamar. It reacts with the excess acid in the stomach, reducing the acidity of the stomach content, which may relieve the symptoms of ulcers, heartburn or dyspepsia. Such products can cause constipation, because the aluminum ions inhibit the contractions of smooth muscle cells in the gastrointestinal tract, slowing peristalsis and lengthening the time needed for stool to pass through the colon. Some such products (such as Maalox) are formulated to minimize such effects through the inclusion of equal concentrations of magnesium hydroxide or magnesium carbonate, which have counterbalancing laxative effects. This compound is also used to control phosphate (phosphorus) levels in the blood of people suffering from kidney failure. Precipitated aluminum hydroxide is included as an adjuvant in some vaccines (e.g. anthrax vaccine). One of the well-known brands of aluminum hydroxide adjuvant is Alhydrogel, made by Brenntag Biosector. Since it absorbs protein well, it also functions to stabilize vaccines by preventing the proteins in the vaccine from precipitating or sticking to the walls of the container during storage. Aluminium hydroxide is sometimes mistakenly called "alum", which properly refers to aluminum potassium sulfate. Vaccine formulations containing aluminum hydroxide stimulate the immune system by inducing the release of uric acid, an immunological danger signal. This strongly attracts certain types of monocytes which differentiate into dendritic cells. The dendritic cells pick up the antigen, carry it to lymph nodes, and stimulate T cells and B cells. It appears to contribute to induction of a good Th2 response, so is useful for immunizing against pathogens that are blocked by antibodies. In the 1960s and 1970s, it was speculated that aluminum was related to various neurological disorders including Alzheimer's disease. Since then, multiple epidemiological studies have found no connection between exposure to aluminum and neurological disorders.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Alhydrogel

Approved Use

Unknown
Primary
Gelusil-Lac

Approved Use

Unknown
Primary
Gastracid

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[TNF-alpha secretion by human macrophage-like cells in response to wear particles and its modification by drugs].
1999 May
The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation.
2004 Aug
Comparison of the response of primary human blood monocytes and the U937 human monocytic cell line to two different sizes of alumina ceramic particles.
2004 Jul
Molecular basis of osteoclastogenesis induced by osteoblasts exposed to wear particles.
2005 May
Alumina nanoparticles induce expression of endothelial cell adhesion molecules.
2008 May 30
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Patents

Patents

Sample Use Guides

Adults and children over 15 years: 1-2 table (400-800ьп). 4 times a day 1 hour after meals and in the evening before bed or if there is discomfort, epigastric pain, heartburn.
Route of Administration: Oral
Bone marrow cells were cultured for 9 d in dendritic cells (DC) culture medium (DC-CM; RPMI 1640 containing GlutaMAX-I; Invitrogen) supplemented with 5% (vol/vol) FCS (Sigma-Aldrich), 50 μ M 2-mercaptoethanol (Sigma-Aldrich), 50 μ g/ml gentamicin (Invitrogen), and 20 ng/ml recombinant mouse GM-CSF (a gift from K. Thielemans, Vrije Universiteit Brussel, Brussels, Belgium). 16 h before harvesting, DCs were exposed either to 10 μ g/ml of OVA, alum (Algeldrate), or OVA-alum suspension.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:54:57 GMT 2023
Edited
by admin
on Fri Dec 15 15:54:57 GMT 2023
Record UNII
LMI26O6933
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALUMINUM OXIDE
HSDB   II   MI  
Common Name English
ALUMINUM OXIDE [II]
Common Name English
ALUMINUM LAKE
Common Name English
ALUMINUM OXIDE, ANHYDROUS [EP IMPURITY]
Common Name English
ALUMINUM OXIDE [HSDB]
Common Name English
ALUMINA [INCI]
Common Name English
ALUMINIUM OXIDE
MART.   WHO-DD  
Common Name English
Aluminium oxide [WHO-DD]
Common Name English
ALUMINIUM LAKE
Common Name English
ALUMINUM OXIDE, ANHYDROUS
EP  
Common Name English
ALUMINIUM OXIDE [MART.]
Common Name English
ALUMINA [HPUS]
Common Name English
ALUMINUM OXIDE, ACTIVATED
Common Name English
ALUMINUM OXIDE [MI]
Common Name English
ALUMINA
HPUS   INCI  
INCI  
Official Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 577
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 576
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
WHO-VATC QD10AX04
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
WHO-ATC D10AX04
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 575
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
Code System Code Type Description
PUBCHEM
9989226
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
CAS
1344-28-1
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
EVMPD
SUB23302
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
NCI_THESAURUS
C77450
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
RXCUI
615
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL3707210
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
HSDB
506
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
WIKIPEDIA
ALUMINIUM OXIDE
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
DAILYMED
LMI26O6933
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
EVMPD
SUB12831MIG
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-691-6
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
DRUG BANK
DB11342
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
CHEBI
30187
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
FDA UNII
LMI26O6933
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
MESH
D000537
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
DRUG CENTRAL
4438
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
CONCEPT Industrial Aid
MERCK INDEX
m1620
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY Merck Index
SMS_ID
100000077698
Created by admin on Fri Dec 15 15:54:57 GMT 2023 , Edited by admin on Fri Dec 15 15:54:57 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY