Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C28H27NO3 |
| Molecular Weight | 425.5189 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC(=CC=C1)C2=CC3=C(C=C2)N(CC4=CC=C(C=C4)C(C)(C)C)C=C3C(=O)C(O)=O
InChI
InChIKey=HSXLMAFNWCSZGP-UHFFFAOYSA-N
InChI=1S/C28H27NO3/c1-18-6-5-7-20(14-18)21-10-13-25-23(15-21)24(26(30)27(31)32)17-29(25)16-19-8-11-22(12-9-19)28(2,3)4/h5-15,17H,16H2,1-4H3,(H,31,32)
| Molecular Formula | C28H27NO3 |
| Molecular Weight | 425.5189 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Wyeth was developing the small molecule plasminogen activator inhibitor-1 (PAI-1) antagonist aleplasinin for the treatment of Alzheimer's disease in the US. PAZ-417 inhibits PAI-I (Plasminogen activator inhibitor-1), thereby increasing the activation of plasminogen to form plasmin. There is some evidence that plasmin can increase the cleavage of amyloid precursor protein at the alpha cleavage site, which could reduce the formation or increase the clearance of amyloid beta, a suspected culprit in Alzheimer's disease. However, it`s development for Alzheimer's disease treatment was discontinued.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:19:02 GMT 2025
by
admin
on
Mon Mar 31 18:19:02 GMT 2025
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| Record UNII |
LL56J87F3X
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
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Official Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C783
Created by
admin on Mon Mar 31 18:19:02 GMT 2025 , Edited by admin on Mon Mar 31 18:19:02 GMT 2025
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10224267
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CHEMBL325424
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TT-15
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481629-87-2
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C76071
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300000034037
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8939
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DB12635
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DTXSID80197447
Created by
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LL56J87F3X
Created by
admin on Mon Mar 31 18:19:02 GMT 2025 , Edited by admin on Mon Mar 31 18:19:02 GMT 2025
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PRIMARY |
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ACTIVE MOIETY |
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