Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C13H19NO2 |
| Molecular Weight | 221.2955 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=CC(O[C@H]2CCNC[C@H]2O)=C1C
InChI
InChIKey=ZHFIAFNZGWCLHU-YPMHNXCESA-N
InChI=1S/C13H19NO2/c1-9-4-3-5-12(10(9)2)16-13-6-7-14-8-11(13)15/h3-5,11,13-15H,6-8H2,1-2H3/t11-,13+/m1/s1
| Molecular Formula | C13H19NO2 |
| Molecular Weight | 221.2955 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Ifoxetine was developed as an unusual drug that specifically and selectively blocks the 5-HT reuptake in the brain without affecting the 5-HT uptake processes in the periphery (blood platelets). The drug was undergoing phase II clinical trials for the treatment of depression; however, the study was suspended.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ifoxetine, a compound with atypical effects on serotonin uptake. | 1986 Oct 14 |
|
| First clinical experience with ifoxetine, a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs. | 1987 Jul |
|
| A case of small cell carcinoma of the kidney. | 2007 Apr |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:34:26 GMT 2023
by
admin
on
Fri Dec 15 17:34:26 GMT 2023
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| Record UNII |
LHH887104B
|
| Record Status |
Validated (UNII)
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| Record Version |
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Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C265
Created by
admin on Fri Dec 15 17:34:26 GMT 2023 , Edited by admin on Fri Dec 15 17:34:26 GMT 2023
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| Code System | Code | Type | Description | ||
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C65884
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71971
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SUB08126MIG
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100000083701
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LHH887104B
Created by
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66208-11-5
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DTXSID10216397
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Ifoxetine
Created by
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CHEMBL2218865
Created by
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C046382
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5805
Created by
admin on Fri Dec 15 17:34:26 GMT 2023 , Edited by admin on Fri Dec 15 17:34:26 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
