FENLEUTON

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H15FN2O3
Molecular Weight	314.311
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C#CC1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O

InChI

InChIKey=MWXPQCKCKPYBDR-UHFFFAOYSA-N

InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)

HIDE SMILES / InChI

Molecular Formula	C17H15FN2O3
Molecular Weight	314.311
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9316110 | https://www.ncbi.nlm.nih.gov/pubmed/9673966

FENLEUTON is a potent, reversible and selective inhibitor of 5-lipoxygenase with IC50 values ranging from 80 to 1100 nM. It was studied for potential use in veterinary medicine to treat chronic obstructive pulmonary disease in horses.

Originator

Approval Year

PubMed

Title	Date	PubMed
Dietary fish oil or lofrin, a 5-lipoxygenase inhibitor, decrease the growth-suppressing effects of coccidiosis in broiler chicks.	1997 Oct	9316110
Pharmacokinetics and pharmacodynamics of fenleuton, a 5-lipoxygenase inhibitor, in ponies.	1998 Mar-Apr	9625466

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:36:45 GMT 2023` Edited by `admin` on `Fri Dec 15 16:36:45 GMT 2023`
Record UNII	LG64454O6I
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FENLEUTON

Official Name

English

N-HYDROXY-N-(4-(3-(4-FLUOROPHENOXY)PHENYL)-3-BUTYN-2-YL)UREA

Systematic Name

English

ABBOTT-76745

Code

English

fenleuton [INN]

Common Name

English

UREA, N-(3-(3-(4-FLUOROPHENOXY)PHENYL)-1-METHYL-2-PROPYNYL)-N-HYDROXY-

Systematic Name

English

FENLEUTON [USAN]

Common Name

English

UREA, N-(3-(3-(4-FLUOROPHENOXY)PHENYL)-1-METHYL-2-PROPYNYL)-N-HYDROXY-, (±)-

Systematic Name

English

LOFRIN

Brand Name

English

A-76745

Code

English

UREA, N-(3-(3-(4-FLUOROPHENOXY)PHENYL)-1-METHYL-2-PROPYN-1-YL)-N-HYDROXY-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1322