Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H13N3 |
| Molecular Weight | 211.2624 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NC(N)=C(C)C2=C1C3=CC=CC=C3N2
InChI
InChIKey=LVTKHGUGBGNBPL-UHFFFAOYSA-N
InChI=1S/C13H13N3/c1-7-12-11(8(2)15-13(7)14)9-5-3-4-6-10(9)16-12/h3-6,16H,1-2H3,(H2,14,15)
| Molecular Formula | C13H13N3 |
| Molecular Weight | 211.2624 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Carcinogenicity in mice and rats of heterocyclic amines in cooked foods. | 1986 Aug |
|
| Tumor induction in mice administered neonatally with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole or 3-amino-1-methyl-5H-pyrido[4,3-b]indole. | 1987 Nov |
|
| Initiating activity in a two-stage mouse skin model of nine mutagenic pyrolysates of amino acids, soybean globulin and proteinaceous food. | 1987 Sep |
|
| Inhibition of human brain aromatic L-amino acid decarboxylase by cooked food-derived 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines. | 1990 Aug 24 |
|
| Antagonism of gamma-aminobutyric acidA receptor-mediated responses by amino-gamma-carbolines. | 1990 Mar |
|
| Inhibition of tryptophan hydroxylase by food-derived carcinogenic heterocyclic amines, 3-amino-1-methyl-5H-pyrido[4,3-b]indole and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole. | 1991 Jan 15 |
|
| Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses. | 1991 May |
|
| The effect of a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), on tyrosine hydroxylase mRNA in PC12h cells. | 1993 May 14 |
|
| Food-derived heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism. | 1994 |
|
| Suppression of chemical mutagen-induced SOS response by alkylphenols from clove (Syzygium aromaticum) in the Salmonella typhimurium TA1535/pSK1002 umu test. | 2001 Aug |
|
| Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust. | 2001 Dec |
|
| Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. | 2001 May 31 |
|
| The heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis in cocultures of rat parenchymal and nonparenchymal liver cells. | 2001 Nov 15 |
|
| Inhibitory effect of curcumin and its natural analogues on genotoxicity of heterocyclic amines from cooked food. | 2002 Dec |
|
| 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (trp-P-1) is incorporated into rat splenocytes, thymocytes, and hepatocytes through monoamine transporters and induces apoptosis. | 2002 Jun |
|
| Inhibitory effect of dibenzoylmethane on mutagenicity of food-derived heterocyclic amine mutagens. | 2003 |
|
| 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) triggers apoptosis by DNA double-strand breaks caused by inhibition of topoisomerase I. | 2004 Jul |
|
| Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines. | 2004 Jul 1 |
|
| Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process. | 2004 Nov 19 |
|
| Chemical synthesis of 2'-deoxyguanosine-C8 adducts with heterocyclic amines: an application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. | 2006 Jun |
|
| Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A. | 2006 Sep |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:44:08 UTC 2023
by
admin
on
Fri Dec 15 17:44:08 UTC 2023
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| Record UNII |
LAH2R5Z22D
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| Record Status |
Validated (UNII)
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DTXSID0043767
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5284474
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62450-06-0
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LAH2R5Z22D
Created by
admin on Fri Dec 15 17:44:08 UTC 2023 , Edited by admin on Fri Dec 15 17:44:08 UTC 2023
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|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
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Heterocyclic amine skin content in cooked food sample. 278?37 pg/g sample.
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 289?38 pg/g sample.
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