SANGIVAMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H15N5O5
Molecular Weight	309.278
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C1C(N)=NC=N3

InChI

InChIKey=OBZJZDHRXBKKTJ-JTFADIMSSA-N

InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C12H15N5O5
Molecular Weight	309.278
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein kinase C (PKC) 44 Target ID: CHEMBL2093867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3338987	Inhibitor 8504		11.0 µM [Ki]
Erk signaling pathway 3 Target ID: Erk signaling pathway Sources: https://www.ncbi.nlm.nih.gov/pubmed/24434142	Inhibitor 8504

PubMed

Title	Date	PubMed
Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells.	2014-02-07	24434142
Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.	2007-11	17956898
Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.	1988-02-05	3338987

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:37:05 GMT 2025` Edited by `admin` on `Mon Mar 31 17:37:05 GMT 2025`
Record UNII	L8YQ8Z3T9T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SANGIVAMYCIN

Common Name

English

NSC-65346

Preferred Name

English

7-DEAZAADENOSINE-7-CARBOXAMIDE

Common Name

English

7H-PYRROLO(2,3-D)PYRIMIDINE-5-CARBOXAMIDE, 4-AMINO-7-.BETA.-D-RIBOFURANOSYL-

Systematic Name

English

4-AMINO-7-.BETA.-D-RIBOFURANOSYL-7H-PYRROLO(2,3-D)PYRIMIDINE-5-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID601028118