SANGIVAMYCIN MONOHYDRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H15N5O5.H2O
Molecular Weight	327.2933
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.NC(=O)C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C1C(N)=NC=N3

InChI

InChIKey=QTYUIEDCERYPNJ-CCUUNMJDSA-N

InChI=1S/C12H15N5O5.H2O/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12;/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16);1H2/t5-,7-,8-,12-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H15N5O5
Molecular Weight	309.278
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein kinase C (PKC) 44 Target ID: CHEMBL2093867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3338987	Inhibitor 8297		11.0 µM [Ki]
Erk signaling pathway 3 Target ID: Erk signaling pathway Sources: https://www.ncbi.nlm.nih.gov/pubmed/24434142	Inhibitor 8297

PubMed

Title	Date	PubMed
Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.	1988 Feb 5	3338987
Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.	2007 Nov	17956898
Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells.	2014 Feb 7	24434142

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:07:50 GMT 2023` Edited by `admin` on `Sat Dec 16 15:07:50 GMT 2023`
Record UNII	5I62P3VF85
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SANGIVAMYCIN MONOHYDRATE

Common Name

English

7H-PYRROLO(2,3-D)PYRIMIDINE-5-CARBOXAMIDE, 4-AMINO-7-.BETA.-D-RIBOFURANOSYL-, HYDRATE (1:1)

Systematic Name

English

Code System Code Type Description

CAS

129601-63-4

Created by admin on Sat Dec 16 15:07:50 GMT 2023 , Edited by admin on Sat Dec 16 15:07:50 GMT 2023

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PUBCHEM

16219974

Created by admin on Sat Dec 16 15:07:50 GMT 2023 , Edited by admin on Sat Dec 16 15:07:50 GMT 2023

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FDA UNII

5I62P3VF85

Created by admin on Sat Dec 16 15:07:50 GMT 2023 , Edited by admin on Sat Dec 16 15:07:50 GMT 2023

PRIMARY

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