ADSB-FUB-187

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NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H31ClFN5O4S
Molecular Weight	564.072
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ADSB-FUB-187

Structure Search

SMILES

CC(C)(C)[C@H](NC(=O)C1=NN(CC2=CC=C(F)C=C2)C3=C1C=CC=C3Cl)C(=O)NCCNS(=O)(=O)C4CC4

InChI

InChIKey=UANJTRHQSBHCID-HSZRJFAPSA-N

InChI=1S/C26H31ClFN5O4S/c1-26(2,3)23(25(35)29-13-14-30-38(36,37)18-11-12-18)31-24(34)21-19-5-4-6-20(27)22(19)33(32-21)15-16-7-9-17(28)10-8-16/h4-10,18,23,30H,11-15H2,1-3H3,(H,29,35)(H,31,34)/t23-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C26H31ClFN5O4S
Molecular Weight	564.072
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:10:12 GMT 2025` Edited by `admin` on `Mon Mar 31 23:10:12 GMT 2025`
Record UNII	L6K9PBL5EO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADSB-FUB-187

Common Name

English

1H-INDAZOLE-3-CARBOXAMIDE, 7-CHLORO-N-((1S)-1-(((2-((CYCLOPROPYLSULFONYL)AMINO)ETHYL)AMINO)CARBONYL)-2,2-DIMETHYLPROPYL)-1-((4-FLUOROPHENYL)METHYL)-

Preferred Name

English

7-CHLORO-N-((2S)-1-(2-(CYCLOPROPYLSULFONYLAMINO)ETHYLAMINO)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)-1-((4-FLUOROPHENYL)METHYL)INDAZOLE-3-CARBOXAMIDE

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-ADSB-FUB-187

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

Code System Code Type Description

FDA UNII

L6K9PBL5EO

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

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EPA CompTox

DTXSID701032540

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

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WIKIPEDIA

ADSB-FUB-187

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

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ADSB-FUB-187 is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of Ki = 0.09 nM and an EC50 of 1.09nM. It was originally developed by Pfizer in 2009, being example 187 from patent WO 2009/106982. While it is the most tightly binding compound from this patent in terms of Ki, it is not the most potent compound at producing a CB1 mediated pharmacological effect, with at least 17 other compounds from the patent having lower EC50 values. Sweden's public health agency suggested classifying ADSB-FUB-187 as hazardous substance on November 10, 2014, following its use as an ingredient in grey-market synthetic cannabis products.

PUBCHEM

44186812

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

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MANUFACTURER PRODUCT INFORMATION

ADSB-FUB-187

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

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CAS

1185283-97-9

Created by admin on Mon Mar 31 23:10:12 GMT 2025 , Edited by admin on Mon Mar 31 23:10:12 GMT 2025

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Related Record Type Details


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ACTIVE MOIETY

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