SRT-3025

Details

Stereochemistry	ACHIRAL
Molecular Formula	C31H31N5O2S2
Molecular Weight	569.74
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(CN6CCCC6)=C5

InChI

InChIKey=MRRXPMZNBRXCPZ-UHFFFAOYSA-N

InChI=1S/C31H31N5O2S2/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37)

HIDE SMILES / InChI

Molecular Formula	C31H31N5O2S2
Molecular Weight	569.74
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.google.com/patents/WO2010071853A1

SIRTUIN MODULATOR 1 is a sirtuin modulator developed by Sirtris Pharmaceuticals, Inc. for treating insulin resistance and metabolic syndrome.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
NAD-dependent deacetylase sirtuin 1 16 Target ID: CHEMBL4506 Sources: https://www.google.com/patents/WO2010071853A1	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Metabolic syndrome 32 Sources: https://www.google.com/patents/WO2010071853A1	Primary		Basic research	Unknown Approved Use Unknown

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The mass spectrometry assay is conducted as follows: 0.5 μM peptide substrate and 120 μM βNAD+ is incubated with 10 nM SIRTl for 25 minutes at 250C in a reaction buffer (50 mM Tris-acetate pH 8, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 5 mM DTT, 0.05% BSA). SIRTUIN MODULATOR 1 was added to the reaction and after the 25 minute incubation with SIRTl, 10 μL of 10% formic acid is added to stop the reaction. Reactions are sealed and frozen for later mass spec analysis

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:07:10 GMT 2023` Edited by `admin` on `Sat Dec 16 18:07:10 GMT 2023`
Record UNII	L4WQ6846SR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SRT-3025

Common Name

English

4-THIAZOLECARBOXAMIDE, 5-(3-METHOXYPROPYL)-2-PHENYL-N-(2-(6-(1-PYRROLIDINYLMETHYL)THIAZOLO(5,4-B)PYRIDIN-2-YL)PHENYL)-

Systematic Name

English

5-(3-METHOXYPROPYL)-2-PHENYL-N-(2-(6-(1-PYRROLIDINYLMETHYL)THIAZOLO(5,4-B)PYRIDIN-2-YL)PHENYL)-4-THIAZOLECARBOXAMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

L4WQ6846SR