Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H36N4O2 |
| Molecular Weight | 448.6003 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCN(CC1)C2=C3C[C@@H](CCC3=C(C)C=C2)NC(=O)C4=CC=C(C=C4)N5CCOCC5
InChI
InChIKey=IHDRUIHIJWCTIY-JOCHJYFZSA-N
InChI=1S/C27H36N4O2/c1-20-3-10-26(31-13-11-29(2)12-14-31)25-19-22(6-9-24(20)25)28-27(32)21-4-7-23(8-5-21)30-15-17-33-18-16-30/h3-5,7-8,10,22H,6,9,11-19H2,1-2H3,(H,28,32)/t22-/m1/s1
| Molecular Formula | C27H36N4O2 |
| Molecular Weight | 448.6003 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:37:00 UTC 2023
by
admin
on
Sat Dec 16 10:37:00 UTC 2023
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| Record UNII |
L3CZ2XB4ER
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID801027304
Created by
admin on Sat Dec 16 10:37:00 UTC 2023 , Edited by admin on Sat Dec 16 10:37:00 UTC 2023
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PRIMARY | |||
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AR-A000002
Created by
admin on Sat Dec 16 10:37:00 UTC 2023 , Edited by admin on Sat Dec 16 10:37:00 UTC 2023
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PRIMARY | AR-A000002 is a drug which is one of the first compounds developed to act as a selective antagonist for the serotonin receptor 5-HT1B, with approximately 10x selectivity for 5-HT1B over the closely related 5-HT1D receptor. It has been shown to produce sustained increases in levels of serotonin in the brain, and has anxiolytic effects in animal studies. | ||
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9846516
Created by
admin on Sat Dec 16 10:37:00 UTC 2023 , Edited by admin on Sat Dec 16 10:37:00 UTC 2023
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PRIMARY | |||
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220051-79-6
Created by
admin on Sat Dec 16 10:37:00 UTC 2023 , Edited by admin on Sat Dec 16 10:37:00 UTC 2023
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PRIMARY | |||
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L3CZ2XB4ER
Created by
admin on Sat Dec 16 10:37:00 UTC 2023 , Edited by admin on Sat Dec 16 10:37:00 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Chemical synthesis of the compound.
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ACTIVE MOIETY |
Class: Antidepressant, Anxiolytic; Mechanism of Action: Serotonin 1B receptor antagonist; Highest Development Phase: Discontinued for Anxiety disorders and Major depressive disorder
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