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Details

Stereochemistry ACHIRAL
Molecular Formula O3Se
Molecular Weight 126.9576
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of SELENITE ION

SMILES

O=[Se]([O-])[O-]

InChI

InChIKey=MCAHWIHFGHIESP-UHFFFAOYSA-L
InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2

HIDE SMILES / InChI

Molecular Formula H2O3Se
Molecular Weight 128.9735
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

The selenite anion is a selenium oxoanion with the chemical formula SeO2−3. A selenite (Se) is a compound that contains this ion. Sodium selenite is an inorganic form of the trace element selenium with potential antineoplastic activity. It was documented that Se deficiency observed in some countries and/or geographic regions (e.g. Keshan region in China), is associated with an increased morbidity and mortality of neoplastic diseases. To correct this problem a number of organic and inorganic selenium compounds were developed and tested. However, it is now firmly established that only an inorganic sodium selenite with four-valent Se, and not that with six-valent (selenate) cation shows anticancer activity. Selenite can undergo redox reaction, for example with protein's sulfhydryl groups expressed on the surface of tumor cells. In this way selenite prevents non-enzymatic formation of parafibrin that coats tumors cells and hence presents them as 'self' to the innate cellular immune system. Consequently, macrophages of the lymphatic system do not recognize neoplastic cells as 'foreign' bodies and spare them from the immune destruction. Sodium selenite also showed promise as a cost-effective, nontoxic anti-inflammatory agent. Treatment with sodium selenite lowers reactive oxygen species (ROS) production, causes a spontaneous reduction in lymphedema volume, increases the efficacy of physical therapy for lymphedema, and reduces the incidence of erysipelas infections in patients with chronic lymphedema. Limited evidence has been presented though that intakes of selenium greater than the amount needed to allow full expression of selenoproteins may have chemopreventive effects against cancer. Controlled intervention studies are needed to fully evaluate selenium as a cancer chemopreventive agent. The US Food and Drug Administration approved a selenium supplement to animal diets; the most common form is sodium selenite for pet foods.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
9.5 μM
4.5 mg/m² single, intravenous
dose: 4.5 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
SELENITE ION plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
200 μM × h
4.5 mg/m² single, intravenous
dose: 4.5 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
SELENITE ION plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
18.25 h
4.5 mg/m² single, intravenous
dose: 4.5 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
SELENITE ION plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 1 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, adult
n = 296
Health Status: unhealthy
Condition: severe sepsis
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
Other AEs: Respiratory failure...
AEs

AEs

AESignificanceDosePopulation
Respiratory failure grade 5
1 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 1 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, adult
n = 296
Health Status: unhealthy
Condition: severe sepsis
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Extradietary supplementation of selenium at the dosage of 200 micrograms per day is generally considered safe and adequate for an adult of average weight subsisting on the typical American diet.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:24:17 UTC 2021
Edited
by admin
on Sat Jun 26 08:24:17 UTC 2021
Record UNII
KXO0259XJ1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SELENITE ION
Common Name English
SELENITE (SEO32-)
Common Name English
SELENITE
Systematic Name English
SELENITE ANION
Common Name English
SELENITE ION(2-)
Common Name English
SELENITE ION (SEO32-)
Common Name English
Code System Code Type Description
CAS
14124-67-5
Created by admin on Sat Jun 26 08:24:18 UTC 2021 , Edited by admin on Sat Jun 26 08:24:18 UTC 2021
PRIMARY
PUBCHEM
1090
Created by admin on Sat Jun 26 08:24:18 UTC 2021 , Edited by admin on Sat Jun 26 08:24:18 UTC 2021
PRIMARY
FDA UNII
KXO0259XJ1
Created by admin on Sat Jun 26 08:24:18 UTC 2021 , Edited by admin on Sat Jun 26 08:24:18 UTC 2021
PRIMARY
RXCUI
9640
Created by admin on Sat Jun 26 08:24:18 UTC 2021 , Edited by admin on Sat Jun 26 08:24:18 UTC 2021
ALTERNATIVE
EPA CompTox
14124-67-5
Created by admin on Sat Jun 26 08:24:18 UTC 2021 , Edited by admin on Sat Jun 26 08:24:18 UTC 2021
PRIMARY
RXCUI
1546398
Created by admin on Sat Jun 26 08:24:18 UTC 2021 , Edited by admin on Sat Jun 26 08:24:18 UTC 2021
PRIMARY
Related Record Type Details
ACTIVE MOIETY