ZD-0892

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H32F3N3O5
Molecular Weight	499.5232
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F

InChI

InChIKey=PNILZVBINXNWHW-FHWLQOOXSA-N

InChI=1S/C24H32F3N3O5/c1-13(2)18(20(31)24(25,26)27)28-22(33)17-7-6-12-30(17)23(34)19(14(3)4)29-21(32)15-8-10-16(35-5)11-9-15/h8-11,13-14,17-19H,6-7,12H2,1-5H3,(H,28,33)(H,29,32)/t17-,18-,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H32F3N3O5
Molecular Weight	499.5232
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.	2005-05-05	15857120
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options.	2005-05	15814847

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:16:39 GMT 2025` Edited by `admin` on `Mon Mar 31 23:16:39 GMT 2025`
Record UNII	KXL5BC5A6F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZD0892

Preferred Name

English

ZD-0892

Code

English

L-PROLINAMIDE, N-(4-METHOXYBENZOYL)-L-VALYL-N-((1S)-3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPROPYL)-

Systematic Name

English

L-PROLINAMIDE, N-(4-METHOXYBENZOYL)-L-VALYL-N-(3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPROPYL)-, (S)-

Systematic Name

English

N-(4-METHOXYBENZOYL)-L-VALYL)-N-((1S)-3,3,3-TR IFLUOR-1-ISOPROPYL2-OXOPROPYL)-L-PROLINAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

9892148