Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C24H32F3N3O5 |
Molecular Weight | 499.5232 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
InChI
InChIKey=PNILZVBINXNWHW-FHWLQOOXSA-N
InChI=1S/C24H32F3N3O5/c1-13(2)18(20(31)24(25,26)27)28-22(33)17-7-6-12-30(17)23(34)19(14(3)4)29-21(32)15-8-10-16(35-5)11-9-15/h8-11,13-14,17-19H,6-7,12H2,1-5H3,(H,28,33)(H,29,32)/t17-,18-,19-/m0/s1
Molecular Formula | C24H32F3N3O5 |
Molecular Weight | 499.5232 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. | 2005 May |
|
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. | 2005 May 5 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:29:47 GMT 2023
by
admin
on
Sat Dec 16 10:29:47 GMT 2023
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Record UNII |
KXL5BC5A6F
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Record Status |
Validated (UNII)
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Record Version |
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-
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Code | English | ||
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9892148
Created by
admin on Sat Dec 16 10:29:48 GMT 2023 , Edited by admin on Sat Dec 16 10:29:48 GMT 2023
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PRIMARY | |||
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ZD 0892
Created by
admin on Sat Dec 16 10:29:48 GMT 2023 , Edited by admin on Sat Dec 16 10:29:48 GMT 2023
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PRIMARY | ZD 0892 is a human neutrophil elastase inhibitor that was under development with AstraZeneca (formed by the merger of Astra and Zeneca in April 1999). | ||
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KXL5BC5A6F
Created by
admin on Sat Dec 16 10:29:48 GMT 2023 , Edited by admin on Sat Dec 16 10:29:48 GMT 2023
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PRIMARY | |||
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DTXSID80938074
Created by
admin on Sat Dec 16 10:29:48 GMT 2023 , Edited by admin on Sat Dec 16 10:29:48 GMT 2023
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PRIMARY | |||
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171964-73-1
Created by
admin on Sat Dec 16 10:29:48 GMT 2023 , Edited by admin on Sat Dec 16 10:29:48 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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ACTIVE MOIETY |