Details
Stereochemistry | ACHIRAL |
Molecular Formula | C31H38N2O5S |
Molecular Weight | 550.709 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(CCN(C)CCCOC2=CC=C(C=C2)S(=O)(=O)C3=C4C=CC=CN4C=C3C(C)C)C=C1OC
InChI
InChIKey=ITAMRBIZWGDOHW-UHFFFAOYSA-N
InChI=1S/C31H38N2O5S/c1-23(2)27-22-33-18-7-6-9-28(33)31(27)39(34,35)26-13-11-25(12-14-26)38-20-8-17-32(3)19-16-24-10-15-29(36-4)30(21-24)37-5/h6-7,9-15,18,21-23H,8,16-17,19-20H2,1-5H3
Molecular Formula | C31H38N2O5S |
Molecular Weight | 550.709 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Fantofarone (SR 33557) is a non-dihydropyridine calcium antagonist with a novel site of action in the L-type Ca2+ channel. Fantofarone is capable of significantly modifying the cardiovascular function without increasing heart rate. Fantofarone was being developed for the treatment of angina pectoris, arrhythmias and hypertension.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9048273
In doses of 100 mg to 150 mg twice daily, monotherapy fantofarone was effective and safe in the treatment of patients with chronic, stable angina pectoris.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2542806
SR 33557 potently antagonized calcium-induced contraction of potassium-depolarized rat aorta in vitro with an IC50 value of 5.6 +/- 0.9 nM, but was a much weaker inhibitor of noradrenaline-induced contraction of the same tissue (IC50 = 96 +/- 22 nM).
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:44:12 GMT 2023
by
admin
on
Sat Dec 16 05:44:12 GMT 2023
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Record UNII |
KU213XYO69
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Record Status |
Validated (UNII)
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Record Version |
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Code | English |
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NCI_THESAURUS |
C471
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NCI_THESAURUS |
C333
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admin on Sat Dec 16 05:44:12 GMT 2023 , Edited by admin on Sat Dec 16 05:44:12 GMT 2023
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m1151
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PRIMARY | Merck Index | ||
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6648
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119349
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DTXSID30150729
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114432-13-2
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KU213XYO69
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100000081762
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CHEMBL285855
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FANTOFARONE
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admin on Sat Dec 16 05:44:12 GMT 2023 , Edited by admin on Sat Dec 16 05:44:12 GMT 2023
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C73029
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SUB07510MIG
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Related Record | Type | Details | ||
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ACTIVE MOIETY |