BETA-SECRETASE 1

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:17:19 GMT 2025` Edited by `admin` on `Tue Apr 01 18:17:19 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	PROTEASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	KS2IHS00QV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BETA-SECRETASE 1

Common Name

English

BACE1

Preferred Name

English

BETA-SITE APP CLEAVING ENZYME 1

Common Name

English

BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1

Common Name

English

MEMAPSIN-2

Common Name

English

Code System Code Type Description

FDA UNII

KS2IHS00QV

Created by admin on Tue Apr 01 18:17:19 GMT 2025 , Edited by admin on Tue Apr 01 18:17:19 GMT 2025

PRIMARY

From	To
1_171	1_375
1_233	1_398
1_285	1_335

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_108
N	1_127
N	1_178
N	1_309

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Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_81] [1_230] [1_234] [1_240] [1_254] [1_255] [1_262]				N6-ACETYLLYSINE	470AD5VY1X
AMINO ACID SUBSTITUTION	[1_453]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL