FENPIVERINIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H29N2O
Molecular Weight	337.4785
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

C[N+]3(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)CCCCC3

InChI

InChIKey=QDIYJDPBMZUZEH-UHFFFAOYSA-O

InChI=1S/C22H28N2O/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25)/p+1

HIDE SMILES / InChI

Molecular Formula	C22H29N2O
Molecular Weight	337.4785
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6719639 | https://www.genome.jp/dbget-bin/www_bget?dr:D07070 | https://www.ncbi.nlm.nih.gov/pubmed/10638099

Fenpiverinium is a quaternary ammonium compound, it is an anticholinergic and antispasmodic agent. It is a constituent of Baralgin. The effects of the constituents of Baralgin (metamizole , fenpiverinium, and pitofenone ) on mechanical activity were studied in isolated human preparations of the upper urinary tract. Fenpiverinium blocked the increase in frequency of phasic-rhythmic contractions and the tonic tension development induced by acetylcholine. Fenpiverinium did influence neither spontaneous phasic activity nor activation by high potassium or norepinephrine. Fenpiverinium has exclusively anticholinergic properties. Fenpiverinium is a muscarinic acetylcholine receptor antagonist.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D07070	Antagonist 2778

PubMed

Title	Date	PubMed
[Effect of Baralgin on isolated preparations of the upper urinary tract in man].	1984	6719639
Analgesics for pain relief after gynaecological surgery. A two-phase study.	1985 Mar 2	3885441
Open labelled evaluation of injection Manyana (a combination of diclofenac + pitofenone + fenpiverinium) in ureteric, biliary and intestinal spasm--a preliminary report.	1999 Sep	10638099

Sample Use Guides

In Vivo Use Guide

A two-phase, double-blind study was performed to assess the efficacy of various drugs in the relief of postoperative pain. Oral analgesia with two compounds (paracetamol 320 mg, caffeine 32 mg, codeine phosphate 8 mg and meprobamate 150 mg (Stopayne; Rio Ethicals) and dipyrone 500 mg, pitofenone hydrochloride 5 mg and fenpiverinium bromide 0,1 mg (Baralgan HS; Albert)) was found to produce satisfactory pain relief, and it is suggested that these oral compounds may be used from 12 hours postoperatively in uncomplicated cases.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:20:05 UTC 2023` Edited by `admin` on `Fri Dec 15 17:20:05 UTC 2023`
Record UNII	KP2L8LC73B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FENPIVERINIUM

Common Name

English

FENPIVERINIUM ION

Common Name

English

1-(3-CARBAMOYL-3,3-DIPHENYLPROPYL)-1-METHYLPIPERIDINIUM

Systematic Name

English

Fenpiverinium [WHO-DD]

Common Name

English

PIPERIDINIUM, 1-(4-AMINO-4-OXO-3,3-DIPHENYLBUTYL)-1-METHYL-

Systematic Name

English

FENPIVERINIUM CATION

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704