AZD-7325

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H19FN4O2
Molecular Weight	354.3782
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AZD-7325

Structure Search

SMILES

CCCNC(=O)C1=C(N)C2=C(N=N1)C(=CC=C2)C3=C(F)C=CC=C3OC

InChI

InChIKey=KYDURMHFWXCKMW-UHFFFAOYSA-N

InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)

HIDE SMILES / InChI

Molecular Formula	C19H19FN4O2
Molecular Weight	354.3782
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

PubMed

Title	Date	PubMed
Development and SAR of functionally selective allosteric modulators of GABAA receptors.	2011 May 1	21498079

Patents

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:52:29 GMT 2023` Edited by `admin` on `Sat Dec 16 01:52:29 GMT 2023`
Record UNII	KNM216XOUH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AZD-7325

Common Name

English

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-METHOXYPHENYL)-N-PROPYL-

Systematic Name

English

AZD 7325 [WHO-DD]

Common Name

English

Code System Code Type Description

PUBCHEM

23581869

Created by admin on Sat Dec 16 01:52:29 GMT 2023 , Edited by admin on Sat Dec 16 01:52:29 GMT 2023

PRIMARY

CAS

942437-37-8

Created by admin on Sat Dec 16 01:52:29 GMT 2023 , Edited by admin on Sat Dec 16 01:52:29 GMT 2023

PRIMARY

DRUG BANK

DB13994

Created by admin on Sat Dec 16 01:52:29 GMT 2023 , Edited by admin on Sat Dec 16 01:52:29 GMT 2023

PRIMARY

ChEMBL

CHEMBL1783282

Created by admin on Sat Dec 16 01:52:29 GMT 2023 , Edited by admin on Sat Dec 16 01:52:29 GMT 2023

PRIMARY

FDA UNII

KNM216XOUH

Created by admin on Sat Dec 16 01:52:29 GMT 2023 , Edited by admin on Sat Dec 16 01:52:29 GMT 2023

PRIMARY

Related Record Type Details


					931QME1Q2W

AZD-7325 HYDROGEN SULFATE

SALT/SOLVATE -> PARENT

Related Record Type Details


					HKJ964L3D4

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-HYDROXYPHENYL)-N-(2-HYDROXYPROPYL)-

METABOLITE -> PARENT

Qualification:

PLASMA


					8NSP69EFK4

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-HYDROXYPHENYL)-

METABOLITE -> PARENT

Qualification:

PLASMA


					U9XE5AS8ZS

7-(2-FLUORO-6-HYDROXY-PHENYL)-2-(1-HYDROXYETHYL)-3H-PYRIMIDO(5,4-C)CINNOLIN-4-ONE

METABOLITE -> PARENT

Qualification:

PLASMA


					3ZYE6PC4UJ

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-METHOXYPHENYL)-

METABOLITE -> PARENT

Qualification:

PLASMA


					VLR32K7Y78

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-METHOXYPHENYL)-N-(2-HYDROXYPROPYL)-

METABOLITE -> PARENT

Qualification:

PLASMA


					2WEE7G5EZV

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-HYDROXYPHENYL)-N-PROPYL-

METABOLITE -> PARENT

Qualification:

PLASMA


					9D9N7S3AA4

7-(2-FLUORO-6-METHOXYPHENYL)-2-(1-HYDROXYETHYL)PYRIMIDO(5,4-C)CINNOLIN-4(3H)-ONE

METABOLITE -> PARENT

Comments:

Metabolites M9, M10, and M42 were either minor or absent in plasma samples after a single dose; however, all became major metabolites in human and preclinical animal plasma after repeated doses and circulated in humans longer than 48 hours after the end of seven repeated doses

Qualification:

PLASMA


					A5AYH46SPV

3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-HYDROXYPHENYL)-N-(1-HYDROXYPROPYL)-

METABOLITE -> PARENT

Qualification:

PLASMA


					VA35G8LX8R

2-ETHYL-7-(2-FLUORO-6-HYDROXYPHENYL)-PYRIMIDO(5,4-C)CINNOLIN-4(3H)-ONE

METABOLITE -> PARENT

Comments:

Metabolites M9, M10, and M42 were either minor or absent in plasma samples after a single dose; however, all became major metabolites in human and preclinical animal plasma after repeated doses and circulated in humans longer than 48 hours after the end of seven repeated doses

Qualification:

PLASMA

Related Record Type Details


					KNM216XOUH

AZD-7325

ACTIVE MOIETY