DISODIUM HEDTA

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H15N2O7.2Na.H
Molecular Weight	322.2228
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[Na+].[Na+].OCCN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=HMMZUOFUYYDMNY-UHFFFAOYSA-L

InChI=1S/C10H18N2O7.2Na/c13-4-3-11(5-8(14)15)1-2-12(6-9(16)17)7-10(18)19;;/h13H,1-7H2,(H,14,15)(H,16,17)(H,18,19);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	H
Molecular Weight	1.0079
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H15N2O7
Molecular Weight	275.2353
Charge	-3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22251571 | https://www.ncbi.nlm.nih.gov/pubmed/22575537

HYDROXYETHYLETHYLENEDIAMINETRIACETIC ACID (HEDTA) is used in cosmetics and care products. It’s a chelating agent, which in combination with selenium was effective in reducing the concentration of Al and level of DNA damage. In addition, experiments with rodents have shown that combination of HEDTA and propolis preserved histological features, mitigated oxidative stress and improved liver, kidney, and brain functions more profoundly.

Approval Year

PubMed

Title	Date	PubMed
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA.	2002	12396676
Effect of N-hydroxyethyl-ethylenediamine-triacetic acid (HEDTA) on Cr(VI) reduction by Fe(II).	2003 Jun	12697190
Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA.	2003 Mar	12643979
Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator.	2003 Mar 15	12654309
Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties.	2003 Sep 24	13129308
Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent.	2004 May 28	18969423
Speciation of chromium(III) and cobalt(III) (amino)carboxylate complexes using capillary electrophoresis.	2005 Jan 1	15623291
Macrocyclic lanthanide complexes as artificial nucleases and ribonucleases: effects of pH, metal ionic radii, number of coordinated water molecules, charge, and concentrations of the metal complexes.	2005 Sep 19	16156622
Iron acquisition by phytosiderophores contributes to cadmium tolerance.	2007 Apr	17337530
Influence of soil type on the mobility and bioavailability of chelated zinc.	2007 May 2	17407310
Homeostatic control of slow vacuolar channels by luminal cations and evaluation of the channel-mediated tonoplast Ca2+ fluxes in situ.	2008	18832189
The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans.	2009 Dec	20019812
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury.	2009 Nov 26	19860434
Development of a novel aluminum tolerance phenotyping platform used for comparisons of cereal aluminum tolerance and investigations into rice aluminum tolerance mechanisms.	2010 Aug	20538888

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:38:14 GMT 2023` Edited by `admin` on `Fri Dec 15 19:38:14 GMT 2023`
Record UNII	KME849MC7A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DISODIUM HEDTA

Common Name

English

GLYCINE, N-(2-(BIS(CARBOXYMETHYL)AMINO)ETHYL)-N-(2-HYDROXYETHYL)-, SODIUM SALT (1:2)

Common Name

English

Code System Code Type Description

RXCUI

1428868