DISODIUM HEDTA

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H15N2O7.2Na.H
Molecular Weight	322.2228
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[Na+].[Na+].OCCN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=HMMZUOFUYYDMNY-UHFFFAOYSA-L

InChI=1S/C10H18N2O7.2Na/c13-4-3-11(5-8(14)15)1-2-12(6-9(16)17)7-10(18)19;;/h13H,1-7H2,(H,14,15)(H,16,17)(H,18,19);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H16N2O7
Molecular Weight	276.2432
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22251571 | https://www.ncbi.nlm.nih.gov/pubmed/22575537

HYDROXYETHYLETHYLENEDIAMINETRIACETIC ACID (HEDTA) is used in cosmetics and care products. It’s a chelating agent, which in combination with selenium was effective in reducing the concentration of Al and level of DNA damage. In addition, experiments with rodents have shown that combination of HEDTA and propolis preserved histological features, mitigated oxidative stress and improved liver, kidney, and brain functions more profoundly.

Approval Year

PubMed

Title	Date	PubMed
Spatial distribution of calcium-gated chloride channels in olfactory cilia.	2010-12-30	21209888
Poly[[[μ(3)-N'-(carboxymethyl)ethylene-di-amine-N,N,N'-triacetato]dysprosium(III)] trihydrate].	2010-10-23	21588859
Development of a novel aluminum tolerance phenotyping platform used for comparisons of cereal aluminum tolerance and investigations into rice aluminum tolerance mechanisms.	2010-08	20538888
Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4.	2010-05-11	20485495
The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans.	2009-12	20019812
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury.	2009-11-26	19860434
Speciation of Zn-aminopolycarboxylic complexes by electrospray ionization mass spectrometry and ion chromatography with inductively coupled plasma mass spectrometry.	2009-02	19127531
Limits of calcium clearance by plasma membrane calcium ATPase in olfactory cilia.	2009	19390572
Polyamine-polycarboxylate metal complexes with different biological effectiveness as nitric oxide scavengers. Clues for drug design.	2008-06-12	18484716
Poly[μ-aqua-diaqua-(μ(3)-N'-carboxy-methyl-ethylenediamine-N,N,N'-tri-acetato)oxidopotassium(I)vanadium(IV)].	2008-06-07	21202763
Solubility and accumulation of metals in Chinese brake fern, vetiver and rostrate sesbania using chelating agents.	2008-02-06	18246709
Homeostatic control of slow vacuolar channels by luminal cations and evaluation of the channel-mediated tonoplast Ca2+ fluxes in situ.	2008	18832189
Kosmotropes enhance the yield of antibody purified by affinity chromatography using immobilized bacterial immunoglobulin binding proteins.	2008	18080884
Determination of sequestering agents in cosmetics and synthetic detergents by high-performance liquid chromatography with ultraviolet detection.	2007-11-09	17920069
A dendrite-autonomous mechanism for direction selectivity in retinal starburst amacrine cells.	2007-07	17622194
Influence of soil type on the mobility and bioavailability of chelated zinc.	2007-05-02	17407310
Iron acquisition by phytosiderophores contributes to cadmium tolerance.	2007-04	17337530
Confirmation of vanadium complex formation using electrospray mass spectrometry and determination of vanadium speciation by sample stacking capillary electrophoresis.	2007-02-28	17386644
Determination of alternative and conventional chelating agents as copper(II) complexes by capillary zone electrophoresis--the first use of didecyldimethylammonium bromide as a flow reversal reagent.	2007-02-12	17386596
Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices.	2007-01	17010641
Effects of lead and chelators on growth, photosynthetic activity and Pb uptake in Sesbania drummondii grown in soil.	2006-11	16522347
Separation of chelating agents as copper complexes by capillary zone electrophoresis using quaternary ammonium bromides as additives in N-methylformamide.	2006-10-27	17723760
Improving sensitivity in simultaneous determination of copper carboxylates by nonaqueous capillary electrophoresis.	2006-03-31	16464460
Neutrophil secretion induced by an intracellular Ca2+ rise and followed by whole-cell patch-clamp recordings occurs without any selective mobilization of different granule populations.	2006	16883058
Equilibrium, kinetic and solvent effect studies on the reactions of [RuIII(Hedta)(H2O)] with thiols.	2005-12-21	16311647
Macrocyclic lanthanide complexes as artificial nucleases and ribonucleases: effects of pH, metal ionic radii, number of coordinated water molecules, charge, and concentrations of the metal complexes.	2005-09-19	16156622
Speciation of chromium(III) and cobalt(III) (amino)carboxylate complexes using capillary electrophoresis.	2005-01-01	15623291
Potential of Hemidesmus indicus for phytoextraction of lead from industrially contaminated soils.	2005-01	15620742
Antioxidant defense in a lead accumulating plant, Sesbania drummondii.	2004-12	15694284
The [Ru(Hedta)NO](0.1-) system: structure, chemical reactivity and biological assays.	2004-11	15522418
Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent.	2004-05-28	18969423
The excitation cascade of Limulus ventral photoreceptors: guanylate cyclase as the link between InsP3-mediated Ca2+ release and the opening of cGMP-gated channels.	2004-02-26	15053840
Biogeochemistry of fluoride in a plant-solution system.	2003-12-17	14674546
Light-catalyzed chromium(VI) reduction by organic compounds and soil minerals.	2003-12-17	14674529
Inactivation of human glutamate dehydrogenase by aluminum.	2003-11	14625697
Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex.	2003-10-01	14512202
Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties.	2003-09-24	13129308
Effect of N-hydroxyethyl-ethylenediamine-triacetic acid (HEDTA) on Cr(VI) reduction by Fe(II).	2003-06	12697190
Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator.	2003-03-15	12654309
Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material.	2003-03	15348476
Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA.	2003-03	12643979
On-column complexation and simultaneous separation of vanadium(IV) and vanadium(V) by capillary electrophoresis with direct UV detection.	2002-10	12373403
Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents.	2002-06-19	12067708
Beneficial effects of humic acid on micronutrient availability to wheat.	2002-03-12	11885604
Determination of strong binding chelators and their metal complexes by anion-exchange chromatography and inductively coupled plasma mass spectrometry.	2002-02-22	11883654
Phytosiderophores influence on cadmium mobilization and uptake by wheat and barley plants.	2002-01-16	11790018
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA.	2002	12396676
EDTA and HEDTA effects on Cd, Cr, and Ni uptake by Helianthus annuus.	2001-10	11572587
High-pressure pulse-radiolysis study of the formation and decomposition of complexes with iron-carbon sigma bonds: mechanistic comparison for different metal centers.	2001-09-10	11531445
Biodegradability of ethylenediamine-based complexing agents and related compounds.	2001-08	11482674

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:51:46 GMT 2025` Edited by `admin` on `Mon Mar 31 19:51:46 GMT 2025`
Record UNII	KME849MC7A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLYCINE, N-(2-(BIS(CARBOXYMETHYL)AMINO)ETHYL)-N-(2-HYDROXYETHYL)-, SODIUM SALT (1:2)

Preferred Name

English

DISODIUM HEDTA

Common Name

English

Code System Code Type Description

RXCUI

1428868