POLATUZUMAB VEDOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 21:28:05 GMT 2025` Edited by `admin` on `Mon Mar 31 21:28:05 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	KG6VO684Z6
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

POLATUZUMAB VEDOTIN

Official Name

English

ACD-79B-VCMMAE

Preferred Name

English

Polatuzumab vedotin [WHO-DD]

Common Name

English

FCU2711

Code

English

RO-5541077000

Code

English

RO-5541077-000

Code

English

RO5541077-000

Code

English

ACD79B-VCMMAE

Code

English

ACD-79BVCMMAE

Code

English

polatuzumab vedotin [INN]

Common Name

English

POLATUZUMAB VEDOTIN [MI]

Common Name

English

POLATUZUMAB VEDOTIN [USAN]

Common Name

English

POLATUZUMAB VEDOTIN [JAN]

Common Name

English

IMMUNOGLOBULIN G1-KAPPA AURISTATIN E CONJUGATE, ANTI-(HOMO SAPIENS CD79B (IMMUNOGLOBULIN-ASSOCIATED CD79 BETA)), HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO AURISTATIN E

Common Name

English

FCU-2711

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN GENE B29 PROTEIN) (HUMAN-MUS MUSCULUS MONOCLONAL MCDS4409A HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL MCDS4409A .KAPPA.-CHAIN, DIMER, THIOETHER WITH N-(((4-((N-(6-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDINYL)-1-OXOH

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C20401

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

EU-Orphan Drug

EU/3/18/2013

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

NCI_THESAURUS

C129823

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

FDA ORPHAN DRUG

547416

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C104153

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

USAN

AB-130

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

DRUG BANK

DB12240

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

FDA UNII

KG6VO684Z6

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

MERCK INDEX

m12150

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

WIKIPEDIA

Polatuzumab vedotin

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

ChEMBL

CHEMBL3301582

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

CAS

1313206-42-6

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

EVMPD

SUB177827

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

RXCUI

2174091

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

ALTERNATIVE

DRUG CENTRAL

5333

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

SMS_ID

100000163521

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

DAILYMED

KG6VO684Z6

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

RXCUI

2174090

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

INN

9714

Created by admin on Mon Mar 31 21:28:05 GMT 2025 , Edited by admin on Mon Mar 31 21:28:05 GMT 2025

PRIMARY

From	To
1_22	1_96
1_144	1_200
1_261	1_321
1_367	1_425
2_22	2_96
2_144	2_200
2_261	2_321
2_367	2_425
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198
1_220	3_218
2_220	4_218
1_226	2_226
1_229	2_229

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					V7I58RC5EJ

MONOMETHYL AURISTATIN E

TOXIN -> CONJUGATE

POLATUZUMAB VEDOTIN-PIIQ

SUB_CONCEPT->SUBSTANCE


					UP5IM9G11J

CD79B

TARGET->CONJUGATED TOXIN

Related Record Type Details


					KG6VO684Z6

POLATUZUMAB VEDOTIN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_220] [1_226] [1_229] [2_220] [2_226] [2_229] [3_218] [4_218]		CYSTEINE	Amount:	Cysteinyl vedotin	6603L01WUR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL