Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H24F3N3O2 |
| Molecular Weight | 431.4508 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NC2=C(C(=O)N1C3=CC=C(OCCCN4CCCC4)C=C3)C(=CC=C2)C(F)(F)F
InChI
InChIKey=DDDZBLNULGDPGA-UHFFFAOYSA-N
InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
| Molecular Formula | C23H24F3N3O2 |
| Molecular Weight | 431.4508 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
MK-0249 is a potent H3 receptor inverse agonist patented by Abbott Laboratories for treatment of cognitive deficits. MK-0249 demonstrates promising results in preclinical models of cognitive disorders. MK0249 has been used in trials studying the treatment of Hypopnea Syndrome, Alzheimer's Disease, Paranoid Schizophrenia ets. Unfortunately, MK-0249 failed to demonstrate efficacy in schizophrenia, mild-to-moderate Alzheimer's Disease, attention-deficit/hyperactivity disorder, and future development has been discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pilot randomized controlled study of a histamine receptor inverse agonist in the symptomatic treatment of AD. | 2012 May |
|
| (11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists. | 2014 Jan |
|
| International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. | 2015 Jul |
Patents
| Substance Class |
Chemical
Created
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admin
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Edited
Sat Dec 16 07:48:57 GMT 2023
by
admin
on
Sat Dec 16 07:48:57 GMT 2023
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| Record UNII |
KF50235Q04
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| Record Status |
Validated (UNII)
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| Record Version |
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