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Details

Stereochemistry RACEMIC
Molecular Formula C18H19NO3
Molecular Weight 297.3484
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLAZIOVINE

SMILES

COC1=CC2=C3C(CC4(C=CC(=O)C=C4)C3=C1O)N(C)CC2

InChI

InChIKey=PNJUPRNTSWJWAX-UHFFFAOYSA-N
InChI=1S/C18H19NO3/c1-19-8-5-11-9-14(22-2)17(21)16-15(11)13(19)10-18(16)6-3-12(20)4-7-18/h3-4,6-7,9,13,21H,5,8,10H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C18H19NO3
Molecular Weight 297.3484
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Glaziovine is a pro-aporphine alkaloid with neuropharmacological properties. Glaziovine is an alkaloid, originally isolated from Ocotea glaziovii (Lauraceae), belonging to the fairly small proaporphine family. In the early 1970's its pharmacology was explored extensively by a pharmaceutical company (Simes S.p.A., Milano), and was registered as a tranquilizer under the trademark Suavedol®. It is also reported to possess anti-ulcer properties in humans.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.008 mM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Antiplatelet aggregation constituents from Annona purpurea.
1998 Dec
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.
2007 Oct 1
Alkaloids from Cinnamomum philippinense.
2012 Dec
Patents

Sample Use Guides

In Vivo Use Guide
Glaziovine-14C 20 mg was administered in capsules (oral route) and in vials (i.v. route).
Route of Administration: Other
Glaziovine exhibits high inhibitory potential against HBsAg with IC50 value of 0.008 mM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:00:37 GMT 2023
Edited
by admin
on Fri Dec 15 16:00:37 GMT 2023
Record UNII
KE7J8A65P6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLAZIOVINE
INN  
INN  
Official Name English
NSC-146052
Code English
glaziovine [INN]
Common Name English
(±)-GLAZIOVINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29701
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
Code System Code Type Description
MESH
C007847
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
FDA UNII
KE7J8A65P6
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
NCI_THESAURUS
C73193
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
INN
3831
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
PUBCHEM
65631
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
SMS_ID
100000080420
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
CAS
17127-48-9
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
ChEMBL
CHEMBL1980854
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
EPA CompTox
DTXSID90864739
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
NSC
146052
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
EVMPD
SUB07911MIG
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY