GLAZIOVINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H19NO3
Molecular Weight	297.3484
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C3C(CC4(C=CC(=O)C=C4)C3=C1O)N(C)CC2

InChI

InChIKey=PNJUPRNTSWJWAX-UHFFFAOYSA-N

InChI=1S/C18H19NO3/c1-19-8-5-11-9-14(22-2)17(21)16-15(11)13(19)10-18(16)6-3-12(20)4-7-18/h3-4,6-7,9,13,21H,5,8,10H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H19NO3
Molecular Weight	297.3484
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/668777 | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072005000300005

Glaziovine is a pro-aporphine alkaloid with neuropharmacological properties. Glaziovine is an alkaloid, originally isolated from Ocotea glaziovii (Lauraceae), belonging to the fairly small proaporphine family. In the early 1970's its pharmacology was explored extensively by a pharmaceutical company (Simes S.p.A., Milano), and was registered as a tranquilizer under the trademark Suavedol®. It is also reported to possess anti-ulcer properties in humans.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hepatitis B virus 8 Target ID: CHEMBL613497 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17723297	Inhibitor 8504		0.008 mM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Stomach ulcer 17 Sources: https://www.ncbi.nlm.nih.gov/pubmed/582915	Primary		Preclinical	Unknown Approved Use Unknown
Psychotic disorder 26 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4211143	Primary		Phase I 438	Unknown Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
441 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/668777/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		GLAZIOVINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status:
1211 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/668777/	20 mg single, intravenous dose: 20 mg route of administration: Intravenous experiment type: SINGLE co-administered:		GLAZIOVINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status:

Doses

Dose	Population	Adverse events
20 mg 1 times / day multiple, oral Highest studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/668777/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: unknown Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/668777/	Sources: https://pubmed.ncbi.nlm.nih.gov/668777/
20 mg single, intravenous Highest studied dose Dose: 20 mg Route: intravenous Route: single Dose: 20 mg Sources: https://pubmed.ncbi.nlm.nih.gov/668777/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: unknown Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/668777/	Sources: https://pubmed.ncbi.nlm.nih.gov/668777/
20 mg single, oral Highest studied dose Dose: 20 mg Route: oral Route: single Dose: 20 mg Sources: https://pubmed.ncbi.nlm.nih.gov/668777/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: unknown Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/668777/	Sources: https://pubmed.ncbi.nlm.nih.gov/668777/

PubMed

Title	Date	PubMed
Alkaloids from Cinnamomum philippinense.	2012-12	23413556
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.	2007-10-01	17723297
Antiplatelet aggregation constituents from Annona purpurea.	1998-12	9868142

Patents

Sample Use Guides

In Vivo Use Guide

Glaziovine-14C 20 mg was administered in capsules (oral route) and in vials (i.v. route).

Route of Administration: Other

In Vitro Use Guide

Glaziovine exhibits high inhibitory potential against HBsAg with IC50 value of 0.008 mM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:16:09 GMT 2025` Edited by `admin` on `Mon Mar 31 18:16:09 GMT 2025`
Record UNII	KE7J8A65P6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-146052

Preferred Name

English

GLAZIOVINE

Official Name

English

glaziovine [INN]

Common Name

English

(±)-GLAZIOVINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29701