GLAZIOVINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H19NO3
Molecular Weight	297.3484
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C3C(CC4(C=CC(=O)C=C4)C3=C1O)N(C)CC2

InChI

InChIKey=PNJUPRNTSWJWAX-UHFFFAOYSA-N

InChI=1S/C18H19NO3/c1-19-8-5-11-9-14(22-2)17(21)16-15(11)13(19)10-18(16)6-3-12(20)4-7-18/h3-4,6-7,9,13,21H,5,8,10H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H19NO3
Molecular Weight	297.3484
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/668777 | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072005000300005

Glaziovine is a pro-aporphine alkaloid with neuropharmacological properties. Glaziovine is an alkaloid, originally isolated from Ocotea glaziovii (Lauraceae), belonging to the fairly small proaporphine family. In the early 1970's its pharmacology was explored extensively by a pharmaceutical company (Simes S.p.A., Milano), and was registered as a tranquilizer under the trademark Suavedol®. It is also reported to possess anti-ulcer properties in humans.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hepatitis B virus 8 Target ID: CHEMBL613497 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17723297	Inhibitor 8297		0.008 mM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Stomach ulcer 15 Sources: https://www.ncbi.nlm.nih.gov/pubmed/582915	Primary		Preclinical	Unknown Approved Use Unknown
Psychotic disorder 26 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4211143	Primary		Phase I 428	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Antiplatelet aggregation constituents from Annona purpurea.	1998 Dec	9868142
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.	2007 Oct 1	17723297
Alkaloids from Cinnamomum philippinense.	2012 Dec	23413556

Patents

Sample Use Guides

In Vivo Use Guide

Glaziovine-14C 20 mg was administered in capsules (oral route) and in vials (i.v. route).

Route of Administration: Other

In Vitro Use Guide

Glaziovine exhibits high inhibitory potential against HBsAg with IC50 value of 0.008 mM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:00:37 GMT 2023` Edited by `admin` on `Fri Dec 15 16:00:37 GMT 2023`
Record UNII	KE7J8A65P6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLAZIOVINE

Official Name

English

NSC-146052

Code

English

glaziovine [INN]

Common Name

English

(±)-GLAZIOVINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29701