U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 13:39:17 GMT 2023
Edited
by admin
on Sat Dec 16 13:39:17 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
KBG15GFL2Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TEMAVIRSEN SODIUM
USAN  
USAN  
Official Name English
RG-101
Code English
TEMAVIRSEN SODIUM [USAN]
Common Name English
RG-2459 SODIUM
Code English
Classification Tree Code System Code
NCI_THESAURUS C281
Created by admin on Sat Dec 16 13:39:18 GMT 2023 , Edited by admin on Sat Dec 16 13:39:18 GMT 2023
Code System Code Type Description
USAN
DE-113
Created by admin on Sat Dec 16 13:39:18 GMT 2023 , Edited by admin on Sat Dec 16 13:39:18 GMT 2023
PRIMARY
NCI_THESAURUS
C152552
Created by admin on Sat Dec 16 13:39:18 GMT 2023 , Edited by admin on Sat Dec 16 13:39:18 GMT 2023
PRIMARY
CAS
1844874-96-9
Created by admin on Sat Dec 16 13:39:18 GMT 2023 , Edited by admin on Sat Dec 16 13:39:18 GMT 2023
PRIMARY
FDA UNII
KBG15GFL2Z
Created by admin on Sat Dec 16 13:39:18 GMT 2023 , Edited by admin on Sat Dec 16 13:39:18 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_7 7 / 19
Deoxyribose (DNA) 1_8-1_9;1_12;1_14;1_16;1_19 6 / 19
1_10-1_11;1_13;1_15;1_17-1_18 6 / 19
Linkage Site Range Site Count
Sodium Phosporothioate 1_1-1_17 17 / 18
1_18 1 / 18
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE_SUBSTITUTION [1_2] [1_4] [1_5] SITE_SPECIFIC 2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION [1_7] SITE_SPECIFIC 2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE 9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION [1_19] SITE_SPECIFIC ADENINE, TEMAVIRSEN MODIFICATION- ZSE1KHQ5QS