U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 13:39:16 GMT 2023
Edited
by admin
on Sat Dec 16 13:39:16 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
KK8BAN51PF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TEMAVIRSEN
USAN  
USAN   INN  
Official Name English
TEMAVIRSEN [USAN]
Common Name English
RG-2459
Code English
temavirsen [INN]
Common Name English
Temavirsen [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C281
Created by admin on Sat Dec 16 13:39:16 GMT 2023 , Edited by admin on Sat Dec 16 13:39:16 GMT 2023
Code System Code Type Description
INN
10564
Created by admin on Sat Dec 16 13:39:16 GMT 2023 , Edited by admin on Sat Dec 16 13:39:16 GMT 2023
PRIMARY
CAS
1637599-57-5
Created by admin on Sat Dec 16 13:39:16 GMT 2023 , Edited by admin on Sat Dec 16 13:39:16 GMT 2023
PRIMARY
USAN
DE-112
Created by admin on Sat Dec 16 13:39:16 GMT 2023 , Edited by admin on Sat Dec 16 13:39:16 GMT 2023
PRIMARY
FDA UNII
KK8BAN51PF
Created by admin on Sat Dec 16 13:39:16 GMT 2023 , Edited by admin on Sat Dec 16 13:39:16 GMT 2023
PRIMARY
NCI_THESAURUS
C152551
Created by admin on Sat Dec 16 13:39:16 GMT 2023 , Edited by admin on Sat Dec 16 13:39:16 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_7 7 / 19
Deoxyribose (DNA) 1_8-1_9;1_12;1_14;1_16;1_19 6 / 19
1_10-1_11;1_13;1_15;1_17-1_18 6 / 19
Linkage Site Range Site Count
Phosphate 1_18 1 / 18
Phosporothioate 1_1-1_17 17 / 18
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET ORGANISM->INHIBITOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE_SUBSTITUTION [1_1] SITE_SPECIFIC ADENINE, TEMAVIRSEN MODIFICATION- ZSE1KHQ5QS
NUCLEOSIDE_SUBSTITUTION 2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION [1_8] SITE_SPECIFIC 2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE 9Q36I4D9VB