U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H24N2O2.2C6H8O6
Molecular Weight 676.665
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of QUININE ASCORBATE

SMILES

OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.OC[C@H](O)[C@H]2OC(=O)C(O)=C2O.COC3=CC4=C(C=CN=C4C=C3)[C@@H](O)[C@@H]5C[C@@H]6CCN5C[C@@H]6C=C

InChI

InChIKey=CJHQUYQRCLIWSW-JPGAVJPLSA-N
InChI=1S/C20H24N2O2.2C6H8O6/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;2*7-1-2(8)5-3(9)4(10)6(11)12-5/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;2*2,5,7-10H,1H2/t13-,14-,19-,20+;2*2-,5+/m000/s1

HIDE SMILES / InChI

Molecular Formula C20H24N2O2
Molecular Weight 324.4168
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula C6H8O6
Molecular Weight 176.1241
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Quinine ascorbate is a salt of antimalarial drug quinine and ascorbic acid (vitamin C). Ascorbate reduces the potency of quinolone-containing anti-malarial drugs. Quinine ascorbate was marketed as a component of over-the-counter smoking deterrent products but was not recognized as safe by the FDA regulation in 1993.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
3.2 μg/mL
8.7 mg/kg single, oral
dose: 8.7 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
QUININE plasma
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
8.4 μg/mL
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
QUININE plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
9.7 μg/mL
300 mg/m² single, intravenous
dose: 300 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
10.6 μg/mL
300 mg/m² single, intramuscular
dose: 300 mg/m²
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
10.3 μg/mL
300 mg/m² single, intragastric
dose: 300 mg/m²
route of administration: Intragastric
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
11.3 μg/mL
300 mg/m² 2 times / day multiple, intramuscular
dose: 300 mg/m²
route of administration: Intramuscular
experiment type: MULTIPLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
28 μg × h/mL
8.7 mg/kg single, oral
dose: 8.7 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
QUININE plasma
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
73 μg × h/mL
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
QUININE plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
90.5 μg × h/mL
300 mg/m² single, intravenous
dose: 300 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
87.2 μg × h/mL
300 mg/m² single, intramuscular
dose: 300 mg/m²
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
95.4 μg × h/mL
300 mg/m² single, intragastric
dose: 300 mg/m²
route of administration: Intragastric
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
12.5 h
300 mg/m² single, intravenous
dose: 300 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
8.4 h
300 mg/m² single, intramuscular
dose: 300 mg/m²
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
13.1 h
300 mg/m² single, intragastric
dose: 300 mg/m²
route of administration: Intragastric
experiment type: SINGLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
9.8 h
300 mg/m² 2 times / day multiple, intramuscular
dose: 300 mg/m²
route of administration: Intramuscular
experiment type: MULTIPLE
co-administered:
QUININE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no [IC50 >133 uM]
no [IC50 >133 uM]
no [IC50 >133 uM]
no [IC50 >133 uM]
no [Inhibition 20 uM]
no [Inhibition 20 uM]
weak
yes [IC50 1.8 uM]
yes [IC50 22.6 uM]
yes [IC50 51.6 uM]
yes [Inhibition 20 uM]
yes [Inhibition 80 uM]
yes [Ki 3.4 uM]
yes
yes
yes
yes
yes
yes
yes
yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
likely
likely
likely
likely
yes [Km 10 uM]
yes [Km 2.6 uM]
yes
yes
yes
yes
yes
yes (co-administration study)
Comment: Coadministration of Ketoconazole increased Quinine AUC by 45% and decreased a mean oral clearance of Quinine by 31%.
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:20:33 GMT 2025
Edited
by admin
on Mon Mar 31 19:20:33 GMT 2025
Record UNII
KAU4V10S2I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
L-ASCORBIC ACID, COMPOUND WITH (8.ALPHA.,9R)-6'-METHOXYCINCHONAN-9-OL (2:1)
Preferred Name English
QUININE ASCORBATE
MART.   USAN  
USAN  
Official Name English
QUININE ASCORBATE [MART.]
Common Name English
L-ASCORBIC ACID, COMPOUND WITH QUININE (2:1)
Common Name English
QUININE ASCORBATE [USAN]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 310.547
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
CFR 21 CFR 310.544
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C152127
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
PUBCHEM
56840788
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
FDA UNII
KAU4V10S2I
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
SMS_ID
300000055058
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
CAS
146-40-7
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
RXCUI
236327
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY RxNorm
ECHA (EC/EINECS)
205-671-5
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
ChEMBL
CHEMBL170
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
EPA CompTox
DTXSID70932743
Created by admin on Mon Mar 31 19:20:33 GMT 2025 , Edited by admin on Mon Mar 31 19:20:33 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE