CLANFENUR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H15ClFN3O2
Molecular Weight	335.761
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C1=C(C(=O)NC(=O)NC2=CC=C(Cl)C=C2)C(F)=CC=C1

InChI

InChIKey=SRLPZQAEBMZCIJ-UHFFFAOYSA-N

InChI=1S/C16H15ClFN3O2/c1-21(2)13-5-3-4-12(18)14(13)15(22)20-16(23)19-11-8-6-10(17)7-9-11/h3-9H,1-2H3,(H2,19,20,22,23)

HIDE SMILES / InChI

Molecular Formula	C16H15ClFN3O2
Molecular Weight	335.761
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800004261 | https://www.ncbi.nlm.nih.gov/pubmed/8157470 | https://www.ncbi.nlm.nih.gov/pubmed/9146040

Clanfenur is a benzoylphenyl urea derivative, developed as an anticancer drug, developed by Solvay. In preclinical studies, clanfenur exhibited anti-tumor activity in mice. A phase I study was initiated to establish the maximum tolerable dose (MTD) and safety of clanfenur. The study had to be discontinued because of intolerance to the vehicle and because the target plasma concentration of 1 ug/mL could not be reached due to very poor solubility of clanfenur.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:39 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:39 GMT 2025`
Record UNII	KAM54NKT1Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(P-CHLOROPHENYL)-3-(6-FLUORO-N,N-DIMETHYLANTHRANILOYL)UREA

Preferred Name

English

CLANFENUR

Official Name

English

clanfenur [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C274