2'-DEOXYADENOSINE TRIPHOSPHATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H16N5O12P3
Molecular Weight	491.1816
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 2'-DEOXYADENOSINE TRIPHOSPHATE

Structure Search

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3

InChI

InChIKey=SUYVUBYJARFZHO-RRKCRQDMSA-N

InChI=1S/C10H16N5O12P3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C10H16N5O12P3
Molecular Weight	491.1816
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Gag-Pol polyprotein 6 Target ID: CHEMBL5823 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19596885	Substrate 661		3.2 µM [Kd]

PubMed

Title	Date	PubMed
Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.	1978 Oct	308954
Formation and degradation of deoxyadenosine nucleotides in inherited adenosine deaminase deficiency.	1982 May	6980023
Importance of platelet-free preparations for evaluating lymphocyte nucleotide levels in inherited or acquired immunodeficiency syndromes.	1983 Dec	6414755
Deoxy-ATP accumulation in adenosine deaminase-inhibited human B and T lymphocytes.	1986	3487921
Heterogeneity of biochemical, clinical and immunological parameters in severe combined immunodeficiency due to adenosine deaminase deficiency.	1987 Dec	3436096
Treatment of cutaneous T cell lymphoma with 2'-deoxycoformycin (pentostatin).	1988 Oct	3263401
Lack of synergy in the inhibition of HIV-1 reverse transcriptase by combinations of the 5'-triphosphates of various anti-HIV nucleoside analogs.	1993 Dec	7506513
Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity.	1998 Aug	9687570
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism.	1998 Nov 10	9811824
Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.	1999 Mar	10092010
Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells.	2001 Apr 15	11304766
Antibodies to guanosine triphosphate misidentified as anti-double-stranded DNA antibodies in a patient with antinuclear antibody-negative lupus, due to buckling of insolubilized assay DNA.	2004 May	15146423
Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity.	2006	17168705
T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking.	2006 Apr 19	16620396
A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.	2007 Oct	17680812
Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.	2008 Dec 23	19105824

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:53:27 GMT 2023` Edited by `admin` on `Sat Dec 16 08:53:27 GMT 2023`
Record UNII	K8KCC8SH6N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2'-DEOXYADENOSINE TRIPHOSPHATE

Systematic Name

English

DATP

Common Name

English

DEOXYADENOSINE 5'-TRIPHOSPHATE

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB03222